Development of a Biomedical Micro/Nano Robot for Drug Delivery

Zhang, Zhenhai; Li, Zhifei; Yü, Wei; Li, Kejie; Xie, Zhihong

doi:10.1166/jnn.2015.9643

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…49 Minimally invasive robotic surgical procedures 50–53 combined with nanorobotics (robots at the scale of a nanometre (10 −9 m)) offers the potential to improve care for patients through nano-procedures (medical and surgical) which do not currently exist. 54,55 Robots can potentially provide companionship in advanced illness. For example, elderly patients with dementia have been shown to gain therapeutic benefit from using a robotic seal (Paro) as a social companion.…”

Section: Resultsmentioning

confidence: 99%

Robotic technology for palliative and supportive care: Strengths, weaknesses, opportunities and threats

et al. 2019

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Background: Medical robots are increasingly used for a variety of applications in healthcare. Robots have mainly been used to support surgical procedures, and for a variety of assistive uses in dementia and elderly care. To date, there has been limited debate about the potential opportunities and risks of robotics in other areas of palliative, supportive and end-of-life care. Aim: The objective of this article is to examine the possible future impact of medical robotics on palliative, supportive care and end-of-life care. Specifically, we will discuss the strengths, weaknesses, opportunities and threats (SWOT) of this technology. Methods: A SWOT analysis to understand the strengths, weaknesses, opportunities and threats of robotic technology in palliative and supportive care. Results: The opportunities of robotics in palliative, supportive and end-of-life care include a number of assistive, therapeutic, social and educational uses. However, there are a number of technical, societal, economic and ethical factors which need to be considered to ensure meaningful use of this technology in palliative care. Conclusion: Robotics could have a number of potential applications in palliative, supportive and end-of-life care. Future work should evaluate the health-related, economic, societal and ethical implications of using this technology. There is a need for collaborative research to establish use-cases and inform policy, to ensure the appropriate use (or non-use) of robots for people with serious illness.

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Section: Resultsmentioning

confidence: 99%

Robotic technology for palliative and supportive care: Strengths, weaknesses, opportunities and threats

et al. 2019

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“…The flagellated bacteria can be attached to the targeted nanoparticles via antibody or hydrophobic binding. 21 , 22 Similar to spermbots, the motility of bacteriobot can also be enhanced by the decoration of magnetic particles. 23 Moreover, compared to the canonical flagellated bacteria, the flagellated magnetotactic bacteria (such as MO-1) contains self-produced magnetosome chain with magnetoresponsive capability.…”

Section: The Design and Control Of Spermbotsmentioning

confidence: 99%

Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives

Zhang,

Wang,

Zhang

et al. 2024

IJN

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Sperm quality is declining dramatically during the past decades. Male infertility has been a serious health and social problem. The sperm cell driven biohybrid nanorobot opens a new era for automated and precise assisted reproduction. Therefore, it is urgent and necessary to conduct an updated review and perspective from the viewpoints of the researchers and clinicians in the field of reproductive medicine. In the present review, we first update the current classification, design, control and applications of various spermbots. Then, by a comprehensive summary of the functional features of sperm cells, the journey of sperms to the oocyte, and sperm-related dysfunctions, we provide a systematic guidance to further improve the design of spermbots. Focusing on the translation of spermbots into clinical practice, we point out that the main challenges are biocompatibility, effectiveness, and ethical issues. Considering the special requirements of assisted reproduction, we also propose the three laws for the clinical usage of spermbots: good genetics, gentle operation and no contamination. Finally, a three-step roadmap is proposed to achieve the goal of clinical translation. We believe that spermbot-based treatments can be validated and approved for in vitro clinical usage in the near future. However, multi-center and multi-disciplinary collaborations are needed to further promote the translation of spermbots into in vivo clinical applications.

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“…And the common methods for preparing micro-nano robots are physical vapor deposition technology [ 6 , 7 ], electrodeposition technology [ 8 , 9 ], controlled assembly technology [ 10 ], 3D printing technology [ 11 , 12 ] and biohybrid technology [ 13 , 14 , 15 ]. The more novel microbial-based micro-nano robots usually use bacteria [ 16 , 17 ], cells [ 1 , 18 , 19 ] or algae [ 20 , 21 ] as the robot itself or propulsion, which are highly biocompatible and biodegradable and can be degraded to noncytotoxic solutes in the biological environment [ 22 , 23 ]. Moreover, single-cell organisms usually have uniform spherical, spiral and linear structures, as well as sizes at the microscale, and they can be easily combined with other artificial materials.…”

Section: Introductionmentioning

confidence: 99%

A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications

Wang,

Chen,

et al. 2023

Micromachines

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Single-cell microrobots are new microartificial devices that use a combination of single cells and artificial devices, with the advantages of small size, easy degradation and ease of manufacture. With externally driven strategies such as light fields, sound fields and magnetic fields, microrobots are able to carry out precise micromanipulations and movements in complex microenvironments. Therefore, single-cell microrobots have received more and more attention and have been greatly developed in recent years. In this paper, we review the main classifications, control methods and recent advances in the field of single-cell microrobot applications. First, different types of robots, such as cell-based microrobots, bacteria-based microrobots, algae-based microrobots, etc., and their design strategies and fabrication processes are discussed separately. Next, three types of external field-driven technologies, optical, acoustic and magnetic, are presented and operations realized in vivo and in vitro by applying these three technologies are described. Subsequently, the results achieved by these robots in the fields of precise delivery, minimally invasive therapy are analyzed. Finally, a short summary is given and current challenges and future work on microbial-based robotics are discussed.

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Development of a Biomedical Micro/Nano Robot for Drug Delivery

Cited by 9 publications

References 16 publications

Robotic technology for palliative and supportive care: Strengths, weaknesses, opportunities and threats

Robotic technology for palliative and supportive care: Strengths, weaknesses, opportunities and threats

Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives

A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications

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