Development of a bovine collagen–apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty

O'Hara, R.; Orr, John; Buchanan, Fraser; Wilcox, Ruth K.; Barton, D.C.; Dunne, Nicholas

doi:10.1016/j.actbio.2012.07.003

Cited by 38 publications

(29 citation statements)

References 42 publications

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“…Compressive strength measurements are performed on cylindrical samples with an aspect ratio of 2 until fracture occurs (Figure 11) [446]. On the other hand, direct tensile strength is difficult to measure in such brittle materials.…”

Section: The Mechanical Propertiesmentioning

confidence: 99%

“…Calcium orthophosphate concretes containing SiO 2 and TiO 2 particles showed a significant (~80–100 MPa) increase in the compressive strength, whilst no change in the mechanical behavior was observed when ZrO 2 particles were added [492]. Additional examples of the properties improving comprise addition of calcium silicates [83], calcium carbonate [71,492], polypeptide copolymers [493], fibrin glue [494] and collagen [446,495,496,497,498,499,500,501,502,503]. Figure 11 shows specimens of an hardened unreinforced calcium orthophosphate formulation (a) and the same formulation reinforced by 5 wt% of bovine collagen fibers (b) after compression loading up to ~15% level of strain.…”

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

“…The characteristic brittle behavior of the set unreinforced formulation can be observed, as the specimen exhibited catastrophic failure after critical loading and subsequently broke into fragments. Observing a typical compression specimen of the set reinforced formulation after testing clearly displays that the failure mechanism was very different, as the specimen maintains a degree of cohesive structure and remains capable of supporting a load [446]. Additionally, strength improvement was found when DCPA and TiO 2 crystals were used as fillers for mechanically activated α-TCP formulations [504].…”

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

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Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Section: The Mechanical Propertiesmentioning

confidence: 99%

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

Section: Reinforced Formulations and Concretesmentioning

confidence: 99%

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Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

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“…Many other works found similar effects after addition of different kinds of fibers in CPC matrices where the faster setting times were attributed to the decrease in the effective L/P ratio due to the penetration of the liquid phase in the interspace between fibers. [3,22] As far as the clinical application is concerned, Driessens et al [23] proposed that adequate initial and final setting times of CPCs were in the range of: 4 min <t setting initial < 8 min and 10 min <t setting final < 15 min. The plasma-treated CPC-PLA composites prepared here displayed initial setting times of 4 min and final setting times of 10 min, falling in the lower range mentioned, so in this sense they can be considered relevant for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Low-Pressure Plasma Treatment of Polylactide Fibers for Enhanced Mechanical Performance of Fiber-Reinforced Calcium Phosphate Cements

Canal

Gallinetti

Ginebra

2014

Plasma Process. Polym.

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Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor mechanical properties limit their applicability to non-stress-bearing applications. The aim of the present work is to evaluate the potential of plasma surface modification of polylactide (PLA) fibers for reinforcement of CPCs. Oxygen low-pressure plasma was employed at different treatment times and the surface properties of the untreated and plasma-treated PLA were evaluated. Plasma treatment on the PLA fibers reduced the setting times of the PLA-CPC composites and improved their flexural properties.

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“…With bone being composed of mainly collagen and apatite, the most logical approach to fabrication of materials for bone replacement may seem to be the structural replication of bone itself 25,26 . Two main problems are, however, associated with this approach.…”

Section: Collagen/apatite Composites Modeled After the Structure Omentioning

confidence: 99%

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

Uskoković

2015

Materials Science and Engineering: C

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Multicomponent, synergistic and multifunctional nanostructures have taken over the spotlight in the realm of biomedical nanotechnologies. The most prospective materials for bone regeneration today are almost exclusively composites comprising two or more components that compensate for the shortcomings of each one of them alone. This is quite natural in view of the fact that all hard tissues in the human body, except perhaps the tooth enamel, are composite nanostructures. This review article highlights some of the most prospective breakthroughs made in this research direction, with the hard tissues in main focus being those comprising bone, tooth cementum, dentin and enamel. The major obstacles to creating collagen/apatite composites modeled after the structure of bone are mentioned, including the immunogenicity of xenogeneic collagen and continuously failing attempts to replicate the biomineralization process in vitro. Composites comprising a polymeric component and calcium phosphate are discussed in light of their ability to emulate the soft/hard composite structure of bone. Hard tissue engineering composites created using hard material components other than calcium phosphates, including silica, metals and several types of nanotubes, are also discoursed on, alongside additional components deliverable using these materials, such as cells, growth factors, peptides, antibiotics, antiresorptive and anabolic agents, pharmacokinetic conjugates and various cell-specific targeting moieties. It is concluded that a variety of hard tissue structures in the body necessitates a similar variety of biomaterials for their regeneration. The ongoing development of nanocomposites for bone restoration will result in smart, theranostic materials, capable of acting therapeutically in direct feedback with the outcome of in situ disease monitoring at the cellular and subcellular scales. Progress in this research direction is expected to take us to the next generation of biomaterials, designed with the purpose of fulfilling Daedalus’ dream - not restoring the tissues, but rather augmenting them.

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Development of a bovine collagen–apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty

Cited by 38 publications

References 42 publications

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate Formulations

Low-Pressure Plasma Treatment of Polylactide Fibers for Enhanced Mechanical Performance of Fiber-Reinforced Calcium Phosphate Cements

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

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