2022
DOI: 10.3892/ijmm.2022.5158
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Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment

Abstract: Cancer cells can acquire resistance to targeted therapeutic agents when the designated targets or their downstream signaling molecules develop protein conformational or activity changes. There is an increasing interest in developing poly-pharmacologic anticancer agents to target multiple oncoproteins or signaling pathways in cancer cells. The microRNA 125a-5p (miR-125a-5p) is a tumor suppressor, and its expression has frequently been downregulated in tumors. By contrast, the anti-apoptotic molecule BIRC5/SURVI… Show more

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Cited by 1 publication
(2 citation statements)
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“…Therefore, multidrug resistance is a serious concern in the treatment of cancer and microbial infections. In mammalian cells, overexpression of the MDR1 gene, which encodes P-glycoprotein, an ATP-binding cassette (ABC) transporter, is a major mechanism underlying multidrug resistance in cancer cells [3][4][5]. Yeast Candida species Candida albicans and Candida glabrata are opportunistic pathogenic microorganisms [1].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, multidrug resistance is a serious concern in the treatment of cancer and microbial infections. In mammalian cells, overexpression of the MDR1 gene, which encodes P-glycoprotein, an ATP-binding cassette (ABC) transporter, is a major mechanism underlying multidrug resistance in cancer cells [3][4][5]. Yeast Candida species Candida albicans and Candida glabrata are opportunistic pathogenic microorganisms [1].…”
Section: Introductionmentioning
confidence: 99%
“…In pathogenic Candida species, the most prevalent mechanism of multidrug resistance involves increased activity of ABC transporters and major facilitator superfamily pumps [6][7][8]. Therefore, the elucidation of multidrug resistance mechanisms in cancer cells and Candida species is needed to develop anticancer and antifungal drugs that overcome multidrug resistance [3,9,10].…”
Section: Introductionmentioning
confidence: 99%