Development of a cancer-specific anterior skull base quality-of-life questionnaire

Gil, Ziv; Abergel, Avraham; Spektor, Sergey; Shabtai, Esther; Khafif, Avi; Fliss, Dan M.

doi:10.3171/jns.2004.100.5.0813

Cited by 126 publications

(125 citation statements)

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“…17 The α score varies from 0 to 1 and a score of 0.70 or higher is considered to be predictive of the reliability of the questionnaire. 2 In this study, we found α-Cornbach values of 0.69 to 1 with most values being !0.75 for each domain, suggesting a good reliability of the ASBS-Q instrument in studying patients undergoing endoscopic skull base surgery. Our study involves a group of patients operated by the same group of surgeons.…”

Section: Discussionmentioning

confidence: 78%

“…2,9 Six relevant domains were identified by factor analysis: role of performance, physical function, vitality, pain, specific symptoms, and impact upon emotions. Internal consistency of each of the six domains was evaluated using Cronbach's α coefficient.…”

Section: Methodsmentioning

confidence: 99%

“…Valid interpretation of the data requires disease-specific instruments, which cover the morbidity associated with the site of cancer and its treatment. 2 The technical development of endonasal surgery has had a major positive impact on the management of patients with Keywords ► quality of life ► endoscopy ► morbidity ► skull base ► sinuses ► craniofacial …”

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confidence: 99%

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Quality of Life Following Endoscopic Resection of Skull Base Tumors

et al. 2012

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There has been an increasing acknowledgment of the importance of topics addressing the quality of life (QOL) of patients with cancer. QOL is assessed in an effort to improve treatment modalities, to promote restoration of the patient's daily function, and to accelerate his return to normal life. Estimation of the influence of specific surgical procedures on QOL can serve as a means by which the most appropriate surgical approach can be selected for a given patient, especially when no single modality has a clear survival advantage over the others. Detailed understanding of the different aspects of QOL may help surgeons improve assessment and management of patients, identify possible obstacle as early as possible during follow-up, and guide the choices of medical interventions. 1 Furthermore, early access of patients to detailed information about their disease can yield better adjustment to an imminent medical condition. A multidimensional evaluation of QOL involves retrieving information on the physical, emotional, social, and economical aspects of the patient's lifestyle, as well as on specific symptoms associated with their disease. Valid interpretation of the data requires disease-specific instruments, which cover the morbidity associated with the site of cancer and its treatment. 2 The technical development of endonasal surgery has had a major positive impact on the management of patients with Keywords ► quality of life ► endoscopy ► morbidity ► skull base ► sinuses ► craniofacial AbstractThe objective of the study is to evaluate patients' quality of life (QOL) after endoscopic resection of skull base tumors. We estimated the QOL of 41 patients who underwent surgery for removal of skull base tumors via the expanded endonasal approach (EEA). The Anterior Skull Base Surgery Questionnaire (ASBS-Q), a multidimensional, diseasespecific instrument containing 36 items was used. The rate of meningitis and cerebrospinal fluid leak was 1.4 and 0%, respectively. There was one case of uniocular visual impairment. The internal consistency of the instrument had a correlation coefficient (α-Cronbach score) of 0.8 to 0.92. Of 41 patients, 30 (75%) reported improvement or no change in overall QOL. Improved scores were reported in the physical function domain and worse scores in the specific symptoms domain. The most significant predictor of poor QOL was female gender, which led to a significant decrease in scores of all domains. Site of surgery, histology, age and comorbidity were not significant predictors of outcome. This paper further validates the use of the ASBS-Q for patients undergoing endoscopic skull base resection. The overall QOL of patients following endoscopic extirpation of skull base tumors is good. Female patients experience a significant decline in QOL compared with males.

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confidence: 78%

Section: Methodsmentioning

confidence: 99%

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Quality of Life Following Endoscopic Resection of Skull Base Tumors

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“…The ASBQ was subsequently demonstrated to have psychometric validity for site-specific QOL assessment following anterior skull base surgery for both transcranial and endoscopic approaches. 4,17 A prospective study of QOL in patients undergoing open anterior skull base surgery has only recently been described. Abergel et al assessed a series of 39 patients with the ASBQ prior to surgery and again at 2 postoperative points.…”

Section: Discussionmentioning

confidence: 99%

Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas

Patel

Raza

McCoul³

et al. 2015

JNS

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T he management of craniopharyngiomas is fraught with challenges that not only hinder achievement of optimal oncological outcomes but potentially have adverse effects on the quality of life (QOL). At time of presentation, and certainly after treatment, craniopharyngiomas can be associated with visual field defects, endocrinopathies, hypothalamic syndromes, increased cardiovascular risk, and neurocognitive sequelae. 7,9,33,37,46 Although considered benign tumors, their location can impact critical structures such as the optic nerves and chiasm, hypoabbreviatioNs ASBQ = Anterior Skull Base Quality of Life; BMI = body mass index; GTR = gross-total resection; QOL = quality of life; obJect Craniopharyngiomas are benign parasellar tumors for which surgical removal, although potentially curative, often leads to morbidity with resulting decreases in quality of life (QOL). The endonasal endoscopic approach is a minimal-access technique for removing these tumors and may reduce postoperative morbidity. The QOL following this method for resection of craniopharyngiomas has not been documented. methods The authors reviewed a database of consecutive endonasal endoscopic surgeries done at Weill Cornell Medical College. Adult patients with histologically proven craniopharyngiomas were included who had completed either only postoperative (> 9 months) or both pre- and postoperative QOL forms, the Anterior Skull Base Quality of Life (ASBQ) questionnaire, and the 22-Item Sinonasal Outcome Test (SNOT-22). Rates of gross-total resection (GTR), complications, and visual and endocrine function were collected. Retrospective independence (Wen score) was also assigned. A contemporaneous group of patients undergoing endonasal endoscopic pituitary macroadenoma resection was used as a control. results This study included 33 procedures performed in 31 patients. The average postoperative ASBQ score was 3.35 and the SNOT-22 score was 19.6. Better QOL was associated with GTR and postoperative radiation. Worse QOL was associated with persistent visual defects, hypopituitarism, tumor recurrence, increase in body mass index, and worsening Wen score. In a subset of 10 patients, both pre- and postoperative (> 9 months) QOL scores were obtained. Both ASBQ and SNOT-22 scores showed stability and a trend toward improvement, from 2.93 ± 0.51 to 2.96 ± 0.47 (ASBQ) and . Compared with 62 patients undergoing endoscopic pituitary macroadenoma resection, patients with craniopharyngiomas had worse postoperative QOL on the ASBQ (3.35 vs 3.80; p = 0.023) and p = 0.12). coNclusioNs This report of validated site-specific QOL following endoscopic surgery for craniopharyngiomas shows an overall maintenance of postoperative compared with preoperative QOL. Better QOL could be seen in patients with GTR and radiation therapy, and worse QOL was found in patients with visual or endocrine deficits. Nevertheless, patients with craniopharyngiomas still had worse QOL than those undergoing similar surgery for pituitary macroadenomas, confirming the worse prognosis of craniop...

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“…Therefore, we used the multidimensional diseasespecific questionnaire for anterior skull base neoplasms developed by Gil and associates to estimate the effect of the endonasal surgical approach for various cranial base lesions on patients' QOL. 9 A higher score in the QOL questionnaire indicates a good outcome, with a minimum score of 1.0 and a maximum score of 5.0.…”

Section: Methodsmentioning

confidence: 99%

Quality of Life Following Endonasal Skull Base Surgery

Pant¹,

Snyderman²,

Bhatki³

et al. 2009

Skull Base

142

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The importance of quality of life (QOL) outcomes following treatments for head and neck tumors are now increasingly appreciated and measured to improve medical and surgical care for these patients. An understanding of the definitions in the setting of health care and the use of appropriate QOL instruments and measures are critical to obtain meaningful information that guides decision making in various aspects of patient health care. QOL outcomes following cranial base surgery is only recently being defined. In this article, we describe the current published data on QOL outcomes following cranial base surgery and provide preliminary prospective data on QOL outcomes and sinonasal morbidity in patients who underwent endonasal cranial base surgery for management of various skull base tumors at our institution. We used a disease-specific multidimensional instrument to measure QOL outcomes in these patients. Our results show that although sinonasal morbidity is increased, this is temporary, and the vast majority of patients have a very good QOL by 4 to 6 months after endonasal approach to the cranial base.

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Development of a cancer-specific anterior skull base quality-of-life questionnaire

Abstract: The proposed questionnaire appears to be sufficiently reliable and valid in estimating a patient's QOL after extirpation of anterior skull base tumors. The instrument can be used in face-to-face interviews and via electronic or regular mail.

Cited by 126 publications

References 29 publications

Quality of Life Following Endoscopic Resection of Skull Base Tumors

Quality of Life Following Endoscopic Resection of Skull Base Tumors

Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas

Quality of Life Following Endonasal Skull Base Surgery

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