Development of a Compact, Cost-Effective Photoacoustic Spectral Response Measurement System for Biomedical Applications

Khan, Suhel; Vasudevan, Srivathsan; Maurya, Mukesh Kumar; Al-Ansari, Ahmed Malalla

doi:10.1109/tim.2023.3284949

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…This theoretical understanding was both confirmed through an experimental investigation involving black rubber and validated via simulation studies, as depicted in Refs. 22 and 23 . These simulation studies revealed that an increase in density leads to a corresponding rise in sound speed, thereby causing a shift in the frequency spectra toward the higher frequency range.…”

Section: Methodsmentioning

confidence: 99%

“…Differentiate Biological Tissues The PASR and its analysis offer a promising sensing method to differentiate samples based on their mechanobiological properties. 23,24 The time-domain PA signal of the different tissue samples was acquired through an ultrasound transducer (OLYMPUS parametric NDT-V303 model, 3.5 MHz center frequency with 8 MHz bandwidth). Time averaging has been implemented to improve the signal-to-noise ratio (SNR) of the acquired signal.…”

Section: Extraction Of the Pasr Spectral Parameters From Frequency Sp...mentioning

confidence: 99%

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Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Khan,

Mukhopadhyay,

Vasudevan

et al. 2024

J. Biomed. Opt.

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The photoacoustic (PA) technique, a noninvasive pump-probe technique, has found interesting applications in biomedical tissue diagnosis over the last decade. To take it a step further to clinical applications, the PA technique needs to be designed as an instrument focusing on a compact design, reducing the cost, and quickly providing a quantitative diagnosis.Aim: This work presents a design and characterization of a cost-effective, compact PA sensing instrument for biomedical tissue diagnosis.Approach: A compact laser diode case design is developed to house several laser diodes for PA excitation, and a pulsed current supply unit is also developed in-house to power the laser diodes to generate a 25 ns current pulse at a frequency of 20 kHz. After PA experimental data acquisition, the signal's frequency spectra were calculated to characterize the tissue quantitatively and correlated with their mechanobiological properties. Results:The corresponding dominant frequency peak in the PA spectral response (PASR) study was low in the fibrofatty normal breast tissue 0.26 AE 0.03 MHz, compared to the dominant frequency peak of 1.60 AE 0.016 MHz in the fibrocystic disease tissue, which had increased glandular and stromal elements, thereby increased tissue density. The histopathological findings correlated with the PASR results, and the fibrocystic breast disease tissue exhibited a higher dominant frequency peak and energy compared to the normal breast tissue. Conclusions:We experimented with an in vitro PASR study of fibrocystic human breast tissues and successfully differentiated different tissue types using quantitative spectral parameters peak frequency, mean frequency, and spectral energy. This gives the potential to take this technique further for cost-effective and quick clinical applications.

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Section: Methodsmentioning

confidence: 99%

Section: Extraction Of the Pasr Spectral Parameters From Frequency Sp...mentioning

confidence: 99%

Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Khan,

Mukhopadhyay,

Vasudevan

et al. 2024

J. Biomed. Opt.

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Transportable Multispectral Optical-Resolution Photoacoustic Microscopy Using Stimulated Raman Scattering Spectrum

Lee,

Park,

Park

et al. 2024

IEEE Trans. Instrum. Meas.

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Development of a Compact, Cost-Effective Photoacoustic Spectral Response Measurement System for Biomedical Applications

Cited by 2 publications

References 28 publications

Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Transportable Multispectral Optical-Resolution Photoacoustic Microscopy Using Stimulated Raman Scattering Spectrum

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