Development of a complex of doxorubicin with nanoparticles based on sodium alginate and viologen calix[4]resorcinol to increase selectivity of cytotoxic action

Abstract

A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) was obtained. Using a set of physicochemical methods, the polymer- macrocycle ratio was found, at which stable nanoparticles are formed, and their morphological characteristics were determined. It was shown that with an increase in the concentration of calix[4]resorcinol, the size of nanoparticles increases and the zeta potential changes from negative to positive values. It was established that the most optimal supramolecular system for DOX binding is a composition with a macrocycle-polymer ratio of 1:50, and a change in the ratio of components can initiate drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system was shown.