Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

Krimmer, J.; Ley, J.; Abellán, Carlos; Cachemiche, J.-P.; Caponetto, L.; Chen, X.; Dahoumane, M.; Dauvergne, D.; Freud, N.; Joly, Baptiste; Lambert, D.; Lestand, Loïc; Létang, J M; Magne, M.; Mathez, H.; Maxim, Voichiţa; Montarou, G.; Morel, C.; Pinto, M.; Ray, C.; Reithinger, V.; Testa, É.; Zoccarato, Y.

doi:10.1016/j.nima.2014.11.042

Cited by 98 publications

(69 citation statements)

References 27 publications

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“…It has been shown experimentally that the longitudinal distribution of such prompt-gamma production is highly correlated to the primary ion range [2], [3]. In the CLaRyS collaboration, two systems for prompt gamma detection are currently under development [4], [5], [6]: a collimated gamma camera and a Compton camera (Fig. 1).…”

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A large area diamond-based beam tagging hodoscope for ion therapy monitoring

et al. 2018

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Abstract-. The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne del'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) polycrystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused (~1 µm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) set-up of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels. therapy. Ions deposit a large fraction of the dose at the end of their path, in the Bragg peak. Compared to conventional X-ray radiotherapy, hadron therapy allows a more efficient dose delivery in the tumor, with a reduction of the dose deposited in the nearby healthy organs. The conformation of the deposited dose to the tumor volume is provided by distributing Bragg peaks in this volume, either spot by spot, or by means of passive scattering and energy degradation. However, since multiple sources of uncertainty on the ion range may cause deviations from the planned dose distribution [1], online control of the ion range is desired in order to reduce safety margins and optimize the ballistic advantage of ion therapy.During an irradiation with ion beams, nuclear reactions occur for part of the projectiles along their path in the patient body, and photons in the range 1-10 MeV are emitted almost isotropically within much less than a picosecond after the reactions. It has been shown experimentally that the longitudinal distribution of such prompt-gamma production is highly correlated to the primary ion range

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A large area diamond-based beam tagging hodoscope for ion therapy monitoring

et al. 2018

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“…Simulations were undertaken to optimize the collimator geometry, by optimizing the fall-o retrieval precision [10]. The localization of the photons behind multi-collimation slits was measured by means of segmented detectors, which validated the use of streaked BGO blocks as detectors [22]. The detector under construction should allow for a determination of the PGPL with millimetric precision at the scale of a single proton spot in pencil beam scanning delivery (≈10 8 incident protons) in the distal region of the tumor.…”

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Prompt-Gamma Monitoring of Proton- and Carbon-Therapy. Combined Development of Time-of-Flight Collimated- and Compton-Cameras

et al. 2015

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Prompt-gamma imaging during ion therapy has proven its ability to control the ion range in real time. The achievable precision is of the order of the millimeter for a single spot in proton pencil beam scanning. Collimated gamma cameras have been developed, that are close to clinical application. The Compton cameras are also under development in various laboratories. Time of ight enables the reduction of the background due to other prompt radiations.

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“…Experimental approaches considered so far are based on tracking secondary protons, [2][3][4][5] detecting prompt-c emission, 6,7 or performing online PET gamma reconstruction. [8][9][10] Several modalities for prompt-c imaging have been investigated: collimated cameras, [11][12][13][14][15] compton cameras [16][17][18][19][20][21][22][23] and prompt-c timing. 24 One important parameter is the production yield of secondary particles used in these methods during treatment, as this will affect the accuracy of the reconstructed dose distribution.…”

Section: Introductionmentioning

confidence: 99%