Development of a Core Outcome Set for Infant Gastroesophageal Reflux Disease

Singendonk, Maartje; Rexwinkel, Robyn; Steutel, Nina F; Gottrand, Frédéric; McCall, Lisa; Orsagh-Yentis, Danielle; Rosen, Rachel; Strisciuglio, Caterina; Thapar, Nikhil; Vandenplas, Yvan; Benninga, Marc A.; Tabbers, Merit M.

doi:10.1097/mpg.0000000000002245

Cited by 15 publications

(21 citation statements)

References 42 publications

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“…In a cohort of 700 children described by Rommel et al, with diverse medical conditions, referred for assessment of severe feeding difficulty, it was the most frequent organic cause of feeding problems, affecting 33% of children in this study [26]. The importance of GERD as a causal factor of oral aversion and feeding difficulties is also underlined by a recent study examining feeding difficulties as a core outcome for GERD [27].…”

Section: Oral Aversion and Dysphagiasupporting

confidence: 52%

Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

Rybak

Sethuraman

Nikaki³

et al. 2020

Nutrients

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Gastrointestinal dysmotility is a common problem in a subgroup of children with intestinal failure (IF), including short bowel syndrome (SBS) and pediatric intestinal pseudo-obstruction (PIPO). It contributes significantly to the increased morbidity and decreased quality of life in this patient population. Impaired gastrointestinal (GI) motility in IF arises from either loss of GI function due to the primary disorder (e.g., neuropathic or myopathic disorder in the PIPO syndrome) and/or a critical reduction in gut mass. Abnormalities of the anatomy, enteric hormone secretion and neural supply in IF can result in rapid transit, ineffective antegrade peristalsis, delayed gastric emptying or gastroesophageal reflux. Understanding the underlying pathophysiologic mechanism(s) of the enteric dysmotility in IF helps us to plan an appropriate diagnostic workup and apply individually tailored nutritional and pharmacological management, which might ultimately lead to an overall improvement in the quality of life and increase in enteral tolerance. In this review, we have focused on the pathogenesis of GI dysmotility in children with IF, as well as the management and treatment options.

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Section: Oral Aversion and Dysphagiasupporting

confidence: 52%

Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

Rybak

Sethuraman

Nikaki³

et al. 2020

Nutrients

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“…8 With this approach, an international COS for infant GERD was developed, J o u r n a l P r e -p r o o f consisting of a total of nine patient-reported and clinical outcomes. 9 Implementing a COS in future systematic reviews, therapeutic intervention trials and clinical management guidelines is essential to increase comparison between studies and may thus provide future recommendations to improve treatment of GERD in children. Therefore, this study describes the development of a COS for GERD in children aged 1-18 years.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…There is no consensus regarding the optimal sample size for a Delphi study; therefore, stakeholder involvement was based on previous COS studies in pediatrics. 5,9,11,12,15 Phase 1 -Qualitative questionnaires Questionnaires were undertaken to:…”

Section: The Development Of This Cos Adheres To Comet Outcome Measures In Rheumatologymentioning

confidence: 99%

Development of a Core Outcome Set for Children Aged 1-18 Years with Gastroesophageal Reflux Disease

Rexwinkel

Henegouwen

Singendonk

et al. 2022

The Journal of Pediatrics

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Although how to measure outcomes were considered in 4 additional articles, 49–52 clear recommendations were not reported. Although future work is planned by 5 COS developers to outline recommendations for how and when to measure outcomes 39,43,44,53,54 and is acknowledged as needed by two, 46,55 17 COSs offer no guidance on how or when to measure outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Ten studies (39%) used language to avoid ambiguity in the list of outcomes to meet this standard. Authors of one study did not meet the standard, describing as a limitationillegible translated outcomes that were not included in the list 53 . In more than half of all COSs (58%) it was unclear if language ambiguity had been considered.…”

Section: Resultsmentioning

confidence: 99%

Core Outcome Sets Relevant to Maternity Service Users: A Scoping Review

Slavin

Creedy

Gamble

2021

J Midwife Womens Health

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Introduction Variation in outcomes reported in maternity‐related clinical trials and practice stifles data synthesis and contributes to ineffective or harmful treatments and interventions. Variation can be addressed using core outcome sets (COSs), minimum agreed sets of outcomes that should be measured and reported in all clinical trials in a specific area of health or health care. This scoping review identified studies that developed maternity‐related COSs; evaluated the extent, scope, quality, and consistency of outcomes across similar COSs; and identified current gaps in evidence. Methods A multifaceted search of 2 COS registers (Core Outcome Measures in Effectiveness Trials, Core Outcomes in Women's and Newborn Health), the International Consortium for Health Outcomes Measurement website, electronic databases (MEDLINE, Embase, CINAHL), and hand search was conducted. Published, English‐language studies describing maternal and neonatal COSs for any health condition and published from inception to January 2020 were included. COS development process was evaluated against recently published COS Standards for Development: scope, stakeholder involvement, and consensus process. Results Thirty‐two articles relating to 26 COSs were included (maternal: 18 articles that addressed 17 COSs; neonatal: 14 articles that addressed 9 COSs) and covered a range of obstetric and neonatal conditions. COSs were published between 2006 and 2020, 58% since 2017. Maternal COSs included more outcomes (median, 17; range, 50) than neonatal COSs (median, 8; range, 20). Overlap in COSs was seen for maternity care and gestational diabetes. Overlap in outcomes was seen across similar COSs, which were mostly inconsistent or poorly defined. No included COS met all minimum standards for development. Two COSs extended recommendations for how and when to measure outcomes. Discussion Growth in COS development in the last 3 years signifies increasing commitment to address variation and improve data synthesis. Although the quality of the development process has improved in the last 3 years, there is a need for improvement. This article presents an urgent need to minimize overlap in outcomes and standardize outcome measurement, case definitions, and timing of measurement between COSs.

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Development of a Core Outcome Set for Infant Gastroesophageal Reflux Disease

Abstract: Not further specified (4), physician (1), oncology pediatrician (1) 2 Pediatric surgeon (2), speech pathologist (1)

Cited by 15 publications

References 42 publications

Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

Development of a Core Outcome Set for Children Aged 1-18 Years with Gastroesophageal Reflux Disease

Core Outcome Sets Relevant to Maternity Service Users: A Scoping Review

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