Development of a deep eutectic solvent-based dispersive liquid–liquid microextraction method followed by back-extraction and diazotization coupled to spectrophotometry for determination of total primary aromatic amines from food simulants

Faraji, Mohammad; Salehi, N Mohammad; Shirani, Mahboube; Mahmoudi-Maymand, Masoumeh

doi:10.1007/s13738-022-02548-1

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…Anilines were determined from food samples through a HDES-based dispersive liquid–liquid extraction with vortex assistance. 33 Bis(2-ethylhexyl) phosphate was mixed in a 1:3 ratio with butylparaben to generate the desired HDES. The extracted anilines were further exposed to a diazotization process, and the final quantification was done via microvolume spectrophotometry.…”

Section: Extraction Techniquesmentioning

confidence: 99%

“…Analyses were done on various brands of drug and plasma samples as well as on live samples, with recovery ranging from 92.0 to 108.6%. Anilines were determined from food samples through a HDES-based dispersive liquid–liquid extraction with vortex assistance . Bis(2-ethylhexyl) phosphate was mixed in a 1:3 ratio with butylparaben to generate the desired HDES.…”

Section: Extraction Techniquesmentioning

confidence: 99%

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Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

et al. 2023

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Deep eutectic solvents (DESs) are multicomponent designer solvents that exist as stable liquids over a wide range of temperatures. Over the last two decades, research has been dedicated to developing noncytotoxic, biodegradable, and biocompatible DESs to replace commercially available toxic organic solvents. However, most of the DESs formulated until now are hydrophilic and disintegrate via dissolution on coming in contact with the aqueous phase. To expand the repertoire of DESs as green solvents, hydrophobic DESs (HDESs) were prepared as an alternative. The hydrophobicity is a consequence of the constituents and can be modified according to the nature of the application. Due to their immiscibility, HDESs induce phase segregation in an aqueous solution and thus can be utilized as an extracting medium for a multitude of compounds. Here, we review literature reporting the usage of HDESs for the extraction of various organic compounds and metal ions from aqueous solutions and absorption of gases like CO 2 . We also discuss the techniques currently employed in the extraction processes. We have delineated the limitations that might reduce the applicability of these solvents and also discussed examples of how DESs behave as reaction media. Our review presents the possibility of HDESs being used as substitutes for conventional organic solvents.

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Section: Extraction Techniquesmentioning

confidence: 99%

Section: Extraction Techniquesmentioning

confidence: 99%

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

et al. 2023

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“…To study the adsorption isotherms of MIPs for MDA, the effect of initial concentration of MDA on the adsorption capacity was also investigated. 5 [20,21]:…”

Section: The Effect Of Initial Concentration Of Mda Onmentioning

confidence: 99%

“…10/2011 [3] stipulates that the specific "nondetectable" migration limit for each kind of PAAs specified in REACH [4] is 0.002 mg/kg food or food simulants, and the total migration for the PAAs not listed in REACH shall not exceed 0.01 mg/kg food or food simulants. In order to meet the determination requirements for PAAs, many detection methods have been developed [1,5]. The most commonly used methods are based on spectrophotometry, chromatography, chromatography-mass spectrometry, and direct analysis in real-time mass spectrometry [1,6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4 $'$ -Methylenedianiline from Food-Contact Materials

Ning

Guo

et al. 2023

Advances in Polymer Technology

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Magnetic molecularly imprinted polymers (MIPs) capable of selectively recognizing and absorbing 4,4 ′ -methylenedianiline (MDA) were successfully synthesized, using Fe3O4 coated with mesoporous silicon (Fe3O4@mSiO2) as the magnetic carrier, 4-vinyl pyridine (4-VP) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, and MDA as the template molecule. The morphology, structure, and properties of MIPs were characterized, suggesting that the MIPs had obvious core-shell structure and strong magnetic responsiveness. The results of adsorption property tests showed that the MIPs could specifically recognize and adsorb MDA with excellent selectivity and reusability. The adsorption kinetic process could be described by the pseudo-second-order kinetic model, and the adsorption isotherm could be fitted by the Langmuir model, with a maximum adsorption capacity of 59.5 μmol/g. Furthermore, the magnetic MIPs have been applied to the electrochemical detection of MDA from the composite film sample, with recoveries in the range from 87.8% to 92.5% and the RSD values less than 4.4%. The prepared magnetic MIPs showed potential for the selective separation and detection of MDA in food-contact materials.

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“…They are known as green solvents which could be used as extraction solvents instead of the common toxic organic solvents such as carbon tetrachloride and dichloromethane. DESs can be easily synthesized by mixing a hydrogen bond acceptor (HBA) and one or two hydrogen bond donor (HBD). − A wide range of HBDs and HBAs have been used to make DESs. These are composed of a mixture of safe, cheap, renewable, and biodegradable organic compounds that are capable of associating with each other through hydrogen bonding and forming a compound that has a melting point far below that of either component .…”

Section: Introductionmentioning

confidence: 99%

Preconcentration of Heterocyclic Aromatic Amines in Edible Fried Insects Using Surfactant-Assisted Hydrophobic Deep Eutectic Solvent for Homogeneous Liquid–Liquid Microextraction prior to HPLC

Katthanet,

Supo,

Jaroensan

et al. 2024

ACS Omega

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Thermal processing techniques are often accompanied by the production of many harmful compounds such as heterocyclic aromatic amines (HAAs). To protect human health, an efficient and environmentally friendly method, namely, homogeneous liquid−liquid microextraction (HLLME), was investigated. This method is based on a surfactant-assisted hydrophobic deep eutectic solvent for the determination of HAAs in edible fried insect samples prior to their analysis by high-performance liquid chromatography coupled with UV detection. A hydrophobic deep eutectic solvent (as extraction solvent) was synthesized using decanoic acid as a hydrogen bond donor and tetrabutylammonium bromide (TBABr) as a hydrogen bond acceptor and then characterized by Fourier transform infrared (FTIR) spectroscopy. The surfactant was used as the emulsifier and induces mass transfer, resulting in an increasing extraction efficiency of the proposed method. Various factors affecting the extraction performance were investigated and optimized. A matrix-match calibration method was used to analyze HAAs in high heat-treated edible fried insect samples. Under optimized conditions, the proposed method showed good linearity (R 2 ≥ 0.99) with satisfactory limits of detection and satisfactory reproducibility with relative standard deviation of less than 10.0%. Furthermore, the procedure greenness was assessed using the Analytical Eco-Scale. This paper represents the first application of HLLME based on a surfactant-assisted hydrophobic deep eutectic solvent to analyze HAAs in edible fried insect samples.

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Development of a deep eutectic solvent-based dispersive liquid–liquid microextraction method followed by back-extraction and diazotization coupled to spectrophotometry for determination of total primary aromatic amines from food simulants

Cited by 7 publications

References 34 publications

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4 $'$ -Methylenedianiline from Food-Contact Materials

Preconcentration of Heterocyclic Aromatic Amines in Edible Fried Insects Using Surfactant-Assisted Hydrophobic Deep Eutectic Solvent for Homogeneous Liquid–Liquid Microextraction prior to HPLC

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Development of a deep eutectic solvent-based dispersive liquid–liquid microextraction method followed by back-extraction and diazotization coupled to spectrophotometry for determination of total primary aromatic amines from food simulants

Cited by 7 publications

References 34 publications

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

Hydrophobic Deep Eutectic Solvents as Greener Substitutes for Conventional Extraction Media: Examples and Techniques

Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4 ′ -Methylenedianiline from Food-Contact Materials

Preconcentration of Heterocyclic Aromatic Amines in Edible Fried Insects Using Surfactant-Assisted Hydrophobic Deep Eutectic Solvent for Homogeneous Liquid–Liquid Microextraction prior to HPLC

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Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4 $'$ -Methylenedianiline from Food-Contact Materials