Development of a dermal cancer slope factor for benzo[a]pyrene

Knafla, A.; Phillipps, K A; Brecher, Ronald W.; Petrovic, Sanya; Richardson, Mark

doi:10.1016/j.yrtph.2006.02.008

Cited by 119 publications

(38 citation statements)

References 25 publications

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“…Although the exact underlying mechanism/s for B(a)P-mediated toxicity is not fully understood, both B(a)P and its metabolites are toxic (for review see Knafla et al, 2006;Wormley and Hood, 2004;Hood et al 2006). In vitro studies with human endothelial cells (RF24 cell line and primary HUVEC), indicated that acute exposure to B(a)P causes a doseand time-dependent cell toxicity (Knaapen AM, 2007).…”

Section: B(a)p-induced Suppression Of Temporal Developmental Expressimentioning

confidence: 99%

Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene

et al. 2007

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The focus of this study was to characterize the impact of gestational exposure to benzo(a)pyrene, [B (a)P] on modulation of glutamate receptor subunit expression that is critical for the maintenance of synaptic plasticity mechanisms during hippocampal or cortical development in offspring. Previous studies have demonstrated that hippocampal and/or cortical synaptic plasticity (as measured by longterm potentiation and S1-cortex spontaneous/evoked neuronal activity) and learning behavior (as measured by fixed-ratio performance operant testing) is significantly impaired in polycyclic aromatic or halogenated aromatic hydrocarbon-exposed offspring as compared to controls. These previous studies have also revealed that brain to body weight ratios are greater in exposed offspring relative to controls indicative of intrauterine growth retardation which has been shown to manifest as low birth weight in offspring. Recent epidemiological studies have identified an effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 Years of life among inner-city children (Perera et al., 2006). The present study utilizes a well-characterized animal model to test the hypothesis that gestational exposure to B(a)P causes dysregulation of developmental ionotropic glutamate receptor subunit expression, namely the N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptor (AMPAR) both critical to the expression of synaptic plasticity mechanisms. To mechanistically ascertain the basis of B(a)P-induced plasticity perturbations, timed pregnant Long-Evans rats were exposed in an oral subacute exposure regimen to 0, 25 and 150µg/kg BW B(a)P on gestation days 14-17. The first sub-hypothesis tested whether gestational exposure to B(a)P would result in significant disposition in offspring. The second sub-hypothesis tested whether gestational exposure to B(a)P would result in downregulation of early developmental expression of NMDA and AMPA receptor subunits in the *Corresponding author: Darryl B. Hood, Ph.D., Department of Neurobiology and Neurotoxicology, Center for Molecular and Behavioral Neuroscience, Meharry Medical College, Nashville, TN 37208, USA. Phone (615) 327-6358, FAX: (615) 327-6632. email: dhood@mmc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. hippocampus of offspring as well as in primary neuronal cultures. The results of these studies revealed significant: 1) disposition to the hippocampus and cortex, 2) down-regulation of developmental glutamate receptor mRNA and protein subunit expres...

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Section: B(a)p-induced Suppression Of Temporal Developmental Expressimentioning

confidence: 99%

Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene

et al. 2007

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“…CSF ingestion , CSF iinhalation , SF dermal is carcinogenic slope factors (7.3, 3.85, 25 mg.kg -1 d -1 , respectively [10-12, 12-11, 13]); BW is body weight (15 kg and 60 kg for child and adult, respectively [10][11][12][11][12][13][14]); AT is the average life span (25550 days [11][12][13][14]); L is lifetime (70 years [10][11][12]); EF is the exposure frequency (180 d.year -1 [10][11][12][11][12][13][14]); ED is the exposure duration (6 and 24 years for child and adult, respectively [10][11][12][11][12][13][14]), IR air is the inhalation rate (5 and 20 m 3 /day for child and adult, respectively [11][12][13][14]), IR soil is the soil intake rate (200 and mg.d -1 for child and adult, respectively [10][11][12][11][12][13][14]); SA is the dermal surface exposure (2800 and 5700 cm 2 for child and adult, respectively [11][12][13][14]); AF is the dermal adherence factor (0.2 and 0.07 mg.cm -2 for child and adult, re...…”

Section: Health Risk Assessment From Pahs Exposurementioning

confidence: 99%

“…The theoretical mutagenic and carcinogenic equivalents of PAH were calculated by multiphying the concentrations in road dust by appropriate mutagenic and carcinogenic potencies relative to BaP and the total values were expressed as BaP-MEQ and BaP-TEQ, respectively which gave the best information of PAH toxicity and were calculated by equation 1, 2 [10,11]. The results showed that total BaP-equivalent concentration ranged from 1.…”

Section: Mutagenic and Carcinogenic Equivalent Of Pahs And Their Contmentioning

confidence: 99%

Human Health Hazard of Polycyclic Aromatic Hydrocarbon in Road Dust in Ha Noi Metropolis

Hà¹

2018

JST

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This study investigates PAHs content in road dust of Hanoi metropolis, Vietnam. The samples were colected from the roads around city and analyzed by gas chromatography mass spectrometry (GC/MS). The total PAHs mass concentration ranges from 33.88 µg/kg to 5588,16 µg/kg, with the mean of 356,24 µg/kg in which HMW accounted up 70 % and LMW made up 30 %. The toxic equivalence factors (TEFs), mutagenic potency equivalent factors (MEFs) and the incremental lifetime cancer risk (ILCR) methodologies were applied to evaluate human exposure to carcinogenic PAHs sources. Carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) were calculated from the potency relative to BaP (TEF) and BaP (MEF). The value of BaP-TEQ for 8 PAHs varied from 1.13 µg/kg to 195.23 µg/kg with mean of 24.34 µg/kg, while the value of BaP-MEQ ranged 1.45 µg/kg to 123.15 µg/kg with mean of 19.96 µg/kg. Basing on ILCRs model, the total cancer risk for children and adults was up to 1.6×10 -5 and 3.9×10 -5 , posing a moderate potential cancer risk, respectively.

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“…The determination of carcinogenic slope factor was based on the cancer-causing ability of Benzo[a]Pyrene; SF Dermal of BaP was 25 (mg/kg/d) À1 (United State Environmental Protection Agency 1994, Knafla et al 2006, Wang 2007. The CS was obtained by converting concentrations of PAHs according to toxic equivalents of Benzo[a]Pyrene using the toxicity equivalency factor (TEF), and the sum was then obtained (Liao and Chiang 2006).…”

Section: Risk Assessment Of Pahsmentioning

confidence: 99%

Determination of polycyclic aromatic hydrocarbons (PAHs) in carbon black-containing plastic consumer products from the Jordanian market

2017

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The concentrations of 13 Polycyclic Aromatic Hydrocarbons (PAHs) were determined using a developed and validated Gas Chromatography/Mass Spectrometry (GC/MS) method in 12 carbon Black-containing rubber and plastic samples collected from the Jordanian market. The total concentrations of the studied PAHs were ranged from 1.25 mg/kg to 528 mg/kg. Both results of Toxicity Equivalent concentration (TEQ) and those of the total estimated cancer risk show that the most dangerous and carcinogenic type of carbon-black containing plastic article is the toy wheel, and the least carcinogenic are the car wiper and toilet plunger samples. The validation parameters were applied on the developed method; the correlation coefficient in linearity test for the 13 PAHs were ranging from 0.9993 to 0.9998 for the concentration range 0.01 to 5 mg/L. Recovery results were ranging between 81.2% and 129%.ARTICLE HISTORY

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Development of a dermal cancer slope factor for benzo[a]pyrene

Cited by 119 publications

References 25 publications

Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene

Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene

Human Health Hazard of Polycyclic Aromatic Hydrocarbon in Road Dust in Ha Noi Metropolis

Determination of polycyclic aromatic hydrocarbons (PAHs) in carbon black-containing plastic consumer products from the Jordanian market

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