Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals

Hassan, Ekram M.; Khamis, E.; El-Kimary, Eman I.; Barary, Magda A.

doi:10.1016/j.talanta.2007.07.006

Cited by 27 publications

(13 citation statements)

References 17 publications

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“…The redox behavior of all the fat soluble vitamins was recently reviewed . The same author and others presented also more recent voltammetric studies in some solvents, such as dichloromethane and acetonitrile but also in water .…”

Section: Fat Soluble Vitaminsmentioning

confidence: 99%

Recent Advances in Electroanalysis of Vitamins

Brunetti

2016

Electroanalysis

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Vitamins are a chemically heterogeneous group of compounds known as essential for the normal functioning of the organic metabolism. Their decrease in humans can lead to several diseases and not being produced by the body, they need to be obtained from dietary sources or supplements. For these reasons, their determination in food, pharmaceutical and clinical samples is crucial. This article reviews key advances in electrochemical measurements of vitamins over the past decade. Particular attention is given to papers proving applicability to real samples analysis. The technical features of the proposed sensors are presented and discussed along with their analytical performances. Future trends and challenges are also addressed.

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Section: Fat Soluble Vitaminsmentioning

confidence: 99%

Recent Advances in Electroanalysis of Vitamins

Brunetti

2016

Electroanalysis

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“…The limit of detection (LOD) and limit of quantification (LOQ), defined as S/N = 3 and 10, respectively, was calculated from the calibration curves to be 263 and 877 nM for the GC electrode and 41 and 138 nM for the H-BDD electrodes, respectively. Hassan demonstrated the determination of VE in pharmaceuticals by DPV technique using a GC electrode [8].…”

Section: Ve Detection With a Flow-injection Systemmentioning

confidence: 99%

“…VE and CoQ 10 are electroactive compounds that can be analyzed by electrochemical techniques. The phenolic group of VE can be oxidized at conventional glassy carbon (GC) electrodes [8], and the voltammetric oxidation peak can be used for the determination. Modified electrodes, e.g.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of lipophilic antioxidants with high sensitivity at boron-doped diamond electrode

Kondo

Sakai

Watanabe

et al. 2013

Electrochimica Acta

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a b s t r a c tThe electrochemical detection of lipophilic antioxidants, ␣-tocopherol (vitamin E, VE) and ubiquinone (coenzyme Q 10 , CoQ 10 ), in methanol and in methanol/hexane mixture solutions, respectively, at borondoped diamond (BDD) electrodes was investigated by cyclic voltammetry (CV) and flow-injection electrochemical measurements. CV measurements revealed that the overpotential for electrochemical reaction of VE and CoQ 10 was larger at an oxidized BDD electrode surface than at that of a hydrogenated BDD (H-BDD) electrode. The slope of the CV calibration curve used to determine the VE and CoQ 10 concentrations was larger at a glassy carbon (GC) electrode than at the H-BDD electrode; however, the signal-to-background ratio was larger at the H-BDD electrode than at the GC electrode, due to the low background feature of the H-BDD electrode. The limit of detection (LOD), defined by a signal-to-noise ratio of three for flow-injection electrochemical detection, was much smaller at the H-BDD electrode (VE: 41 nM and CoQ 10 : 17 nM) than at the GC electrode (VE: 263 nM and CoQ 10 : 71 nM). These results confirm that the H-BDD electrode is reliable for the electrochemical detection of lipophilic antioxidants, especially at low concentrations.

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“…DPV was developed for determining silymarin/vitamin E acetate mixtures in pharmaceuticals [25]. Vitamin E acetate gave well-resolved, diffusion-controlled anodic peaks at +444 mV (versus Ag/AgCl) in Britton-Robinson buffer at pH 2.8.…”

Section: Introductionmentioning

confidence: 99%

MWNT-modified electrodes for voltammetric determination of lipophilic vitamins

Ziyatdinova

Morozov

Budnikov

2011

J Solid State Electrochem

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Multi-walled carbon nanotube modified graphite electrodes (MWNT-GEs) have been created for the voltammetric determination of α-tocopherol and retinol. The electrode surface was characterized by atomic force microscopy. The MWNT-GEs presented structured surfaces and a significant (26-fold) increase in roughness over unmodified graphite electrodes (8.2 vs. 0.32 nm for MWNT-GEs and GEs, respectively). Their surfaces consisted of aggregates with a highly regular "thorn-like" structure. α-Tocopherol and retinol were oxidized on the bare GEs and the MWNT-GEs in 0.1 M HClO 4 in acetonitrile. Decreases in the overpotential of 0.2 and 0.04 V for α-tocopherol and retinol, respectively, and increased oxidation currents were observed on the MWNT-GEs in comparison with the unmodified electrodes. The calibration graphs were linear in the range 0.065-2.00 mM for α-tocopherol and 0.05-1.50 mM for retinol. The detection limits were found to be 0.05 and 0.04 mM for α-tocopherol and retinol, respectively. The developed electrodes were applied to determine α-tocopherol and retinol in pharmaceuticals. The results obtained agreed well with coulometric titration data.

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Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals

Cited by 27 publications

References 17 publications

Recent Advances in Electroanalysis of Vitamins

Recent Advances in Electroanalysis of Vitamins

Electrochemical detection of lipophilic antioxidants with high sensitivity at boron-doped diamond electrode

MWNT-modified electrodes for voltammetric determination of lipophilic vitamins

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