Development of a dosimetric model for in vitro labelled cells with β ⁺ emitters in PET tracking studies

Abstract

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Using radial distribution functions to calculate cellular cross-absorbed dose for β emitters: comparison with reference methods and application for 18F-FDG cell labeling

“…If we consider a distribution of non-overlapping cells, however, the rdf will not be as simple and will depend on the spatial configuration of the cells. In the literature, two types of configuration are typically used to model cell distributions: a lattice structure (Cai et al (2017), Jacquemin et al (2019), Net & Howell (2010)) or a uniformly random distribution (Falzone et al (2019)). Both were illustrated on figure 2 (left) with their respective rdf (right).…”

“…Cellular S(r) values are specific to a given radionuclide, cell size, source-to-target region combination and cell-to-cell distance r. They can be generated by the software MIRDCell for several radionuclides using an analytical approach described in Goddu et al (Goddu et al (1993)), or calculated using Monte Carlo simulations (Jacquemin et al (2019), Marcatili et al (2016)).…”

“…Several studies helped to better understand the relationship between the activity distribution, particle energies and geometric considerations on the self-and cross-dose and their respective effect on the biologic response (Rajon et al (2011), Goddu et al (1993), Jacquemin et al (2019), Makrigiorgos et al (2017), R. W. Howell and Prasad V. S. V. Neti (2005)). The MIRDCell software has been a key tool in that regard to explore the impact of non-uniformity radionuclide distribution in cells on the absorbed dose response in 2D and 3D cell populations, in addition to provide cellular S values data (Vaziri et al (2014)).…”

“…2D monolayer, or 3D cell clusters in close-packing geometry (Cai et al (2010), Freudenberg et al (2011), Gholami et al (2018)). Otherwise, the use of a generic approach based on tabulated cellular S values is more appropriate and works well for any cell configuration and radionuclide type (Vaziri et al (2014), Marcatili et al (2016), Makrigiorgos et al (2017), Jacquemin et al (2019), Goddu et al (1993)). The method requires the creation of virtual cell coordinates for a specific geometry and determination of relative distances to eventually sum the dose contributions to a selected target cell.…”

“…function (rdf), a mathematical tool commonly used to analyze the structure of materials. The tool was used in our case to describe the spatial configuration of cells either arranged in a lattice (Faraggi et al (1998), Cai et al (2017), Jacquemin et al (2019)) or randomly distributed (Falzone et al (2019), Marcatili et al (2016)).…”