Development of a fermented goats' milk containing <i>Lactobacillus rhamnosus: in vivo</i>
 study of health benefits

Salva, Susana; Nuñez, Martha Susana; Villena, Julio; Ramón, Adriana Noemí; Font, Graciela; Álvarez, Susana

doi:10.1002/jsfa.4467

Cited by 77 publications

(74 citation statements)

References 52 publications

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“…In our laboratory, several Lactobacillus strains isolated from goatÕs milk were evaluated according to their capacity to modulate respiratory immunity and we found that Lactobacillus rhamnosus CRL1505, administered by the oral route at the proper dose, was able to increase S. pneumoniae clearance rates in lung and blood, reduce lung injuries, and increase the survival of infected mice (10). We also demonstrated that the protective effect of the CRL1505 strain can be achieved in immunocompromised malnourished mice and that it was related to an upregulation of both innate and specific immune responses in the respiratory tract (11). To elucidate the immunological mechanisms involved in the increased resistance to pneumococcal infection induced by L. rhamnosus CRL1505, we performed studies of B cell populations in BM.…”

Section: Introductionmentioning

confidence: 69%

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Barbieri

Villena

Herrera

et al. 2013

The Journal of Nutrition

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The ability of nasally administered Lactobacillus rhamnosus CRL1505 to accelerate the recovery of respiratory B cell-mediated immunity against pneumococcal infection in replete malnourished mice was evaluated. Weaned mice were malnourished after consumption of a protein-free diet for 21 d. Malnourished mice were fed a balanced conventional diet (BCD) for 7 d (BCD group) or a BCD for 7 d with supplemental L. rhamnosus CRL1505 by the nasal route during the last 2 d (BCD+Lr group). Nonreplete malnourished and normal mice were used as the malnourished (MNC) and the well-nourished (WNC) control groups, respectively. Mice were challenged with Streptococcus pneumoniae at the end of each dietary treatment. The immune response was studied before the challenge and at different times postinfection. The MNC mice had less resistance to pneumococcal infection, fewer mature and immature B cells in lung and spleen, and a reduced production of specific antibodies compared with WNC mice. The BCD treatment did not induce a complete normalization of the number B cell populations and antibody amounts. However, the BCD+Lr group had normal numbers of spleen and lung B cells. Moreover, the BCD+Lr mice had a significantly lower susceptibility to S. pneumoniae infection and higher amounts of anti-pneumococcal antibodies. Although further studies are necessary to clarify the effect of malnutrition and nasally administered lactobacilli in other immune cell populations involved in the protection against respiratory pathogens, this work gives evidence of the importance of using nasal priming with probiotics to accelerate the recovery of respiratory immunity in immunocompromised malnourished hosts.

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Section: Introductionmentioning

confidence: 69%

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Barbieri

Villena

Herrera

et al. 2013

The Journal of Nutrition

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“…Minervini et al (2009), developed fermented goat milk with a mixed starter culture (Streptococcus thermophilus CR12, Lactobacillus Helveticas PR4 and Lactobaillus plantarum 1288) which resulted in production of GABA, an inhibiting signal substance in the central nervous system, and provoked an in vitro ACE-inhibitory activity, which counteract high blood pressure. Recently, fermented goat milk (Lactobacillus rhamnosus CRL1505) was demonstrated to stimulate the mucosal immune system and improve the defense against intestinal and respiratory infections in a mouse immunosuppressant model (Salva et al, 2011). As mentioned above, one disadvantage with goat milk is the almost nonexistent content of folic acid.…”

Section: Effect On Infancy Intakementioning

confidence: 99%

Composition, nutritional and therapeutic values of goat milk: A review

Yadav

Singh

Yadav

2016

AJDFR

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Goat is one of the main contributors of milk and meat products. Goat milk is different from cow and human milk in composition, nutritional and therapeutic attributes. The compositional differences are of significance in indicating the technological suitability for goat milk processing and its products. The differences in composition of cow milk and goat milk may result into the products with different sensory characteristics, nutritional and therapeutic values. Goat milk contains higher amount of Ca, Mg and P than cow and human milk but vitamin D, vitamin B 12 and folate contents are less. Goat milk is recommended for infants, old and convalescent people. Three fatty acids viz., caproic, caprylic and capric have great medicinal values for patients suffering from a variety of ailments. Further, it is worthwhile to compare the milk of goats with that of cows and note benefits or limitations which may result from differences found. Goat milk products other than cheese and pasteurized milk are considered to be the diary products with greatest marketing potential. Therefore, several characteristic of goat milk are currently the focus of increased research interest. Fermented goat milk incorporating live probiotic cells represent a group of products with great prospects in the future with regard to their nutritive and therapeutic properties.

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“…Some few studies reported that nasally administered heat-killed immunobiotics are capable of improving resistance against respiratory pathogens (50, 61, 84, 85) (Table 1). In this regard, studies by Hori et al (50) showed that the nasal priming with heat-killed L. casei Shirota significantly augmented the resistance of adult BALB/c mice to influenza virus by stimulating respiratory tract cellular immunity.…”

Section: Local Modulation Of Respiratory Anti-viral Immunity By L Rhmentioning

confidence: 99%

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Kitazawa

Villena

2014

Front. Immunol.

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Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and young children. Host immune response is implicated in both protective and immunopathological mechanisms during RSV infection. Activation of Toll-like receptor (TLR)-3 in innate immune cells by RSV can induce airway inflammation, protective immune response, and pulmonary immunopathology. A clear understanding of RSV–host interaction is important for the development of novel and effective therapeutic strategies. Several studies have centered on whether probiotic microorganisms with the capacity to stimulate the immune system (immunobiotics) might sufficiently stimulate the common mucosal immune system to improve defenses in the respiratory tract. In this regard, it was demonstrated that some orally administered immunobiotics do have the ability to stimulate respiratory immunity and increase resistance to viral infections. Moreover, during the last decade scientists have significantly advanced in the knowledge of the cellular and molecular mechanisms involved in the protective effect of immunobiotics in the respiratory tract. This review examines the most recent advances dealing with the use of immunobiotic bacteria to improve resistance against viral respiratory infections. More specifically, the article discuss the mechanisms involved in the capacity of the immunobiotic strain Lactobacillus rhamnosus CRL1505 to modulate the TLR3-mediated immune response in the respiratory tract and to increase the resistance to RSV infection. In addition, we review the role of interferon (IFN)-γ and interleukin (IL)-10 in the immunoregulatory effect of the CRL1505 strain that has been successfully used for reducing incidence and morbidity of viral airways infections in children.

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Development of a fermented goats' milk containing Lactobacillus rhamnosus: in vivo study of health benefits

Abstract: Goats' milk fermented with L. rhamnosus CRL1505 could be manufactured as an alternative probiotic dairy product since this new food has the ability to stimulate the common mucosal immune system and to improve defenses against respiratory and intestinal infections.

Cited by 77 publications

References 52 publications

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Composition, nutritional and therapeutic values of goat milk: A review

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

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