Development of a Fine Ceramic Heart Valve for Use as a Cardiac Prosthesis

Mitamura, Yoshinori; Mikami, Tomohisa; Yuta, Toshio; Matsumoto, Takero; Shimooka, Toshiyuki; Okamoto, Eiji; Eizuka, Noriyuki; Yamaguchi, Kensei

doi:10.1097/00002480-198609000-00012

Cited by 25 publications

(9 citation statements)

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“…However, ion plating has not been extensively explored in biomedical engineering. A TiN coating several micrometers thick deposited by ion plating onto a titanium prosthetic heart valve cage was first introduced by Mitamura et al [299]. Many of the papers that follow have focused on dental prostheses in which Co-Cr-Mo alloys are commonly employed [300][301][302][303].…”

Section: Ion Platingmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,077

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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Section: Ion Platingmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,077

1,477

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“…Favorable results have been reported for applications such as surgical needles for corneal surgery, 8 materials for total joint replacement, 3,9 orthopedic pins and screws, 10 dental prostheses, 11 medical guidewires, 12 heart valve replacements, 13 and rotary pumps for left ventricular assistance. 14 The use of TiN for dental prostheses [15][16][17][18] and for hip joint and heart valve replacements 19,20 has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption and platelet attachment and activation, on TiN, TiC, and DLC coatings on titanium for cardiovascular applications

Jones

McColl

Grant

et al. 2000

J. Biomed. Mater. Res.

284

151

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The hemocompatibility of a TiN/TiC/diamond-like carbon (DLC) multilayer structure, deposited on titanium substrates for use as coatings for a heart valve prosthesis, has been studied through the adsorption of blood proteins and the adhesion and attachment of blood platelets. All of the surfaces were characterized by stylus profilometry and water contact angles. The adsorption of albumin and fibrinogen to the surfaces was assessed using the Amido Black assay, whereas platelet attachment was studied by scanning electron microscopy and quantified using stereological techniques. The degree of platelet spreading on the surfaces was seen to correlate with differences in surface energy, indicated from contact angle measurements. The greatest spreading was seen on the more hydrophilic surfaces. When studying protein adsorption to the surfaces, no correlation could be determined between contact angle results and levels of adsorption, although the most hydrophilic surfaces did appear to promote greater amounts of fibrinogen adsorption. Thrombus formation was observed to some degree on all of the surfaces, with the exception of the DLC coating. This coating also promoted less spreading of platelets than the other surfaces. The good hemocompatibility of the DLC coating is attributed to its hydrophobicity and smooth surface, resulting in a higher ratio of albumin to fibrinogen than any of the other surfaces.

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“…It would exhibit even better wear properties and would allow for more slender construction because of its strength but it might not provide enough mechanical grip for stable tissue growth. The same appears to be true for the second new development which is single crystal alumina, used in Japan by Mitamura et al (1985) to make the occluders for disc valvzs in implantable ventricular assist devices. They reported that there was little thrombus formation during Gott ring tests, and none at all on the valves themselves.…”

Section: Reviewmentioning

confidence: 78%

“…They reported that there was little thrombus formation during Gott ring tests, and none at all on the valves themselves. They went on (Mitamura et al, 1986) to study the strength and fracture toughness of the single crystal alumina, together with the titanium nitride used for the valve body, and concluded that they were superior to pyrolitic carbon which, as mentioned earlier, is the benchmark. It would be unfortunate therefore if these exceptional properties could not be combined with the ability to form a tissue covering.…”

Section: Reviewmentioning

confidence: 98%

The Use of Ceramics in Prosthetic Heart Valves

Gentle

1987

Engineering in Medicine

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A survey is carried out of how various ceramics have been used or considered as materials for prosthetic heartvalves. The ceramics include pyrolitic carbon, titanium dioxide, porous and fully dense alumina, and single crystal alumina. Particular attention is paid to the ability of some types of alumina to support a stable tissue covering which then camouflages them from further interactions with the blood.

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Development of a Fine Ceramic Heart Valve for Use as a Cardiac Prosthesis

Cited by 25 publications

References 0 publications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Protein adsorption and platelet attachment and activation, on TiN, TiC, and DLC coatings on titanium for cardiovascular applications

The Use of Ceramics in Prosthetic Heart Valves

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