Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

Jung, Yuna; Jin, Ji Hye; Kim, Youngseo; Oh, Jung Hyub; Moon, Heechang; Jeong, Huisu; Kim, Jaehoon; Park, Yoon Kyung; Oh, Yohan; Park, Sungnam; Kim, Dokyoung

doi:10.1039/d2ob00830k

Cited by 11 publications

(4 citation statements)

References 55 publications

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“…, functional groups as the A moiety (Chart 3). 36–38,40,43,48,51,52,54–64 One of these molecules (Chart 3, molecule 13l ) exhibits interesting polymorphism-dependent emission, as well as reversible mechanochromism. 54 Some of these molecules (Chart 3, molecules 16a–i ) emit from green to orange both in solution and solid state.…”

Section: Existing Literaturementioning

confidence: 99%

meta-Fluorophores: an uncharted ocean of opportunities

Chatterjee,

Mandal,

Mardanya

et al. 2023

Chem. Commun.

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Section: Existing Literaturementioning

confidence: 99%

meta-Fluorophores: an uncharted ocean of opportunities

Chatterjee,

Mandal,

Mardanya

et al. 2023

Chem. Commun.

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“…The use of molecules with differing partitioning behaviors and fluorescence properties also enables multiple structures to be tracked over time with minimal photodamage. Properly designed probes can report multiple attributes of the microenvironment including membrane fluidity, local polarity, lipid composition, domain sizes, and temporal properties (145)(146)(147)(148)(149)(150)(151)(152)(153)(154)(155)(156)(157)(158)160). Newer probes such as PIE-1 possess high fluorescence quantum yield and photostability, further improving upon measurement attributes for live cell imaging including imaging speed (147).…”

Section: Fluorescence Microscopymentioning

confidence: 99%

Analytical Techniques for Single-Cell Biochemical Assays of Lipids

Yao

Vaithiyanathan

Allbritton

2023

Annu. Rev. Biomed. Eng.

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Lipids are essential cellular components forming membranes, serving as energy reserves, and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is associated with a wide range of diseases including cancer and autoimmunity. Heterogeneity in cell behavior including lipid signaling is increasingly recognized as a driver of disease and drug resistance. This diversity in cellular responses as well as the roles of lipids in health and disease drive the need to quantify lipids within single cells. Single-cell lipid assays are challenging due to the small size of cells (∼1 pL) and the large numbers of lipid species present at concentrations spanning orders of magnitude. A growing number of methodologies enable assay of large numbers of lipid analytes, perform high-resolution spatial measurements, or permit highly sensitive lipid assays in single cells. Covered in this review are mass spectrometry, Raman imaging, and fluorescence-based assays including microscopy and microseparations. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 25 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…Because of other exceptional properties such as facile four step synthesis without the need for column purification, environmentally insensitive behaviour, and possible additional functionalization, this compound was further modified in later reports, i. e. with an attached dodecyl chain at the anilines for vesicle formation [79] and therefore lipid droplets visualization. [80] …”

Section: The Non‐classic Approach To Sssesmentioning

confidence: 99%

Design Concepts for Solution and Solid‐State Emitters – A Modern Viewpoint on Classical and Non‐Classical Approaches

Huber

Dubbert

Scherz

et al. 2022

Chemistry A European J

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For a long time, luminescence phenomena were strictly distinguished between the emission of isolated molecules in dilute solutions or close‐packed structures such as in powders or aggregates. This changed with the breakthrough observation of dual‐state efficient materials, which led to a rapid boost of publications examining the influence of structural features to achieve balanced emission with disregarded molecular surroundings. Some first general structural design concepts have already been proposed based on reoccurring patterns and pivotal motifs. However, we have found another way to classify these solution and solid‐state emitters (SSSEs). Hence, this minireview aims to present an overview of published structural features of SSSEs while shining light on design concepts from a more generalized perspective. Since SSSEs are believed to bridge the gap of hitherto known aggregation‐sensitive compound classes, we hope to give future scientists a versatile tool in hand to efficiently design novel luminescent materials.

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Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

Abstract: Lipid droplets (LDs) are crucial biological organelles connected with metabolic pathways in biological systems and diseases. To monitor the locations and accumulations of LDs in lipid-related diseases, developing a visualization...

Cited by 11 publications

References 55 publications

meta-Fluorophores: an uncharted ocean of opportunities

meta-Fluorophores: an uncharted ocean of opportunities

Analytical Techniques for Single-Cell Biochemical Assays of Lipids

Design Concepts for Solution and Solid‐State Emitters – A Modern Viewpoint on Classical and Non‐Classical Approaches

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