2021
DOI: 10.1016/j.ijpharm.2020.120121
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Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate

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Cited by 39 publications
(26 citation statements)
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“…phosphate nanoparticles have a diffusion coefficient in water lower than mannitol (2.7 × 10 −7 cm 2 /s vs. 2.9 × 10 −6 cm 2 /s) [27,28] Therefore, during droplet evaporation, a porous shell of nanoparticles is formed, allowing the residual core solvent to evaporate. In this case, the morphology of the dried particles depends on the chemical nature, concentration, mechanical properties of the materials forming the shell, and the nanoparticle colloidal interactions [29,30]. The accumulation of nanoparticles at the particle surface during drying, in presence of a low amount of mannitol, weakened the resistance of the shell curvature.…”
Section: Particle Morphology Of Doe Powdersmentioning
confidence: 99%
“…phosphate nanoparticles have a diffusion coefficient in water lower than mannitol (2.7 × 10 −7 cm 2 /s vs. 2.9 × 10 −6 cm 2 /s) [27,28] Therefore, during droplet evaporation, a porous shell of nanoparticles is formed, allowing the residual core solvent to evaporate. In this case, the morphology of the dried particles depends on the chemical nature, concentration, mechanical properties of the materials forming the shell, and the nanoparticle colloidal interactions [29,30]. The accumulation of nanoparticles at the particle surface during drying, in presence of a low amount of mannitol, weakened the resistance of the shell curvature.…”
Section: Particle Morphology Of Doe Powdersmentioning
confidence: 99%
“…This vaccine combined with chemotherapy induced a strong and durable Th1-type cellular immune response, prolonged survival time, decreased bacterial burden in organs, reduced pathological damage, and enhanced the chemotherapy effect in mouse and monkey models with TB ( Bertholet et al., 2010 ; Baldwin et al., 2021 ). In addition, a stable, inhalable dry powder version of ID93/GLA-SE has already been developed as an alternative to injectable administration ( Gomez et al., 2021 ). At present, phase I clinical trials of this vaccine is underway, however, participants have not been recruited (ClinicalTrials.gov Identifier: NCT03806686 and NCT03806699, respectively).…”
Section: Tuberculosis Therapeutic Vaccinesmentioning
confidence: 99%
“…For single-use disposable DPIs [ 133 , 134 ], the device is used once and then discarded. They are the preferred device when the drug product is administered just a few times (e.g., vaccines [ 135 ] or inhaled oxytocin for the prevention of post-partum hemorrhage [ 136 ]), when the dosing regimen calls for less frequent dosing (e.g., once weekly as in ABIP), or when the patient is immunocompromised and there is concern about the risk of infection when reusing the device. It has been suggested that single-use devices may also be preferred for amorphous powder formulations as accumulation of residual amorphous powder in the device can negatively impact device performance at elevated RH.…”
Section: Novel Devices For High Dose Deliverymentioning
confidence: 99%