Development of a Hemostatic Urinary Catheter for Transurethral Prostatic Surgical Applications

Jones, James M.; Gannett, Cole; Jones, Mattie; Winata, Ervelyn; Zhu, Meihua; Buckley, Lisa; Lazar, Jack; Hedges, Jason C.; McCarthy, Simon J.; Xie, Hua

doi:10.1016/j.urology.2022.03.037

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…[22b,23] During prostate surgery, the surgical wound often bleeds due to the presence of the pampiniform venous plexus. [24] Considering the quick gelation and tissue adhesion characteristics of the GACM spray, we postulated that the GACM hydrogel could efficiently seal wounds and promote hemostasis. To test this hypothesis, we evaluate the hemostatic capability of the GACM spray by prostate bleeding model (Figure S15, Supporting Information).…”

Section: Adhesive and Electrical Performance Of Gacmmentioning

confidence: 99%

In Situ‐Sprayed Bioinspired Adhesive Conductive Hydrogels for Cavernous Nerve Repair

Wang,

Yang

et al. 2024

Advanced Materials

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Cavernous nerve injury (CNI), resulting in erectile dysfunction (ED), poses a significant threat to the quality of life for men. Strategies utilizing conductive hydrogels have demonstrated promising results for the treatment of peripheral nerves with a large diameter (> 2 mm). However, integrating convenient minimally invasive operation, anti‐swelling and immunomodulatory conductive hydrogels for treating small‐diameter injured cavernous nerves remains a great challenge. Here, we developed a sprayable adhesive conductive hydrogel (GACM) composed of gelatin, adenine, carbon nanotubes, and mesaconate designed for cavernous nerve repair. Multiple hydrogen bonds provided GACM with excellent adhesive and antiswelling properties, enabling it to establish a conformal electrical bridge with the damaged nerve and aiding in the regeneration process. Additionally, mesaconate‐loaded GACM suppressed the release of inflammatory factors by macrophages and promoted the migration and proliferation of Schwann cells. In vivo tests demonstrated that the GACM hydrogel repaired the cavernous nerve and restored erectile function and fertility. Furthermore, we validated the feasibility of sprayable GACM in minimally invasive robotic surgery in beagles. Given the benefits of therapeutic effectiveness and clinical convenience, our research suggests a promising future for sprayable GACM materials as advanced solutions for minimally invasive nerve repair.This article is protected by copyright. All rights reserved

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Section: Adhesive and Electrical Performance Of Gacmmentioning

confidence: 99%