Development of a high angular resolution diffusion imaging human brain template

Varentsova, Anna; Zhang, Shengwei; Arfanakis, Konstantinos

doi:10.1016/j.neuroimage.2014.01.009

Cited by 111 publications

(105 citation statements)

References 42 publications

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“…Single-subject images (FA, T2-weighted) and Bn labels were aligned to a brain diffusion template in Montreal Neurological Institute (MNI) space (Illinois Institute of Technology [IIT] human brain atlas, v.3, Chicago, IL) (Varentsova et al, 2014). Specifically, FA maps in single-subject native space were registered to the mean FA image (n = 72) of the IIT human brain atlas (alignment-Native-to-IITMNI) by the use of the Advanced Normalization Tool (ANTs, Philadelphia, PA) (Avants et al, 2011).…”

Section: Mri Data Analysismentioning

confidence: 99%

Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems

et al. 2015

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Brainstem nuclei (Bn) in humans play a crucial role in vital functions, such as arousal, autonomic homeostasis, sensory and motor relay, nociception, sleep, and cranial nerve function, and they have been implicated in a vast array of brain pathologies. However, an in vivo delineation of most human Bn has been elusive because of limited sensitivity and contrast for detecting these small regions using standard neuroimaging methods. To precisely identify several human Bn in vivo, we employed a 7 Tesla scanner equipped with multi-channel receive-coil array, which provided high magnetic resonance imaging sensitivity, and a multi-contrast (diffusion fractional anisotropy and T2-weighted) echo-planar-imaging approach, which provided complementary contrasts for Bn anatomy with matched geometric distortions and resolution. Through a combined examination of 1.3 mm 3 multi-contrast anatomical images acquired in healthy human adults, we semi-automatically generated in vivo probabilistic Bn labels of the ascending arousal (median and dorsal raphe), autonomic (raphe magnus, periaqueductal gray), and motor (inferior olivary nuclei, two subregions of the substantia nigra compatible with pars compacta and pars reticulata, two subregions of the red nucleus, and, in the diencephalon, two subregions of the subthalamic nucleus) systems. These labels constitute a first step toward the development of an in vivo neuroimaging template of Bn in standard space to facilitate future clinical and research investigations of human brainstem function and pathology. Proof-of-concept clinical use of this template is demonstrated in a minimally conscious patient with traumatic brainstem hemorrhages precisely localized to the raphe Bn involved in arousal.

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Section: Mri Data Analysismentioning

confidence: 99%

Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems

et al. 2015

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“…For the longitudinal analysis, each individual's initial and follow-up scan was co-registered to generate a within-subject template representing a halfway transformation between the two timepoints, prior to construction of a group atlas [19]. Group atlases were registered to the Illinois Institute of Technology standard brain atlas, version 4.0 [22]. Transformation matrices were generated for each stage of registration to create a deformation field that defines the mapping directly from each individual's native scan space to standard space in a single interpolation [19].…”

Section: Imaging Analysismentioning

confidence: 99%

Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

Leyton

Hodges

et al. 2015

JAD

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Abstract.Background: Clinico-pathological distinction of primary progressive aphasia (PPA) can be challenging at clinic presentation. In particular, cross-sectional neuroimaging signatures across the logopenic (lvPPA) and semantic (svPPA) variants are difficult to establish, with longitudinal profiles showing greater divergence. Objective: Assess longitudinal propagation of white matter degradation in lvPPA and svPPA to determine disease progression over time, and whether this reflects distinct underlying pathology. Method: A cohort of 27 patients with dementia (12 lvPPA; 15 svPPA) and 12 healthy controls were assessed at baseline and 1-year follow-up on the Addenbrooke's Cognitive Examination-Revised and Sydney Language Battery. Diffusion weighted images were collected at both time-points and analyzed for longitudinal white matter change using DTI-TK and TBSS. Results: LvPPA patients showed a significant decline in naming and repetition, over 1 year, while svPPA patients declined in naming and comprehension. Longitudinal imaging revealed widespread bilateral degradation of white matter tracts in lvPPA over a 1-year period with early involvement of the left posterior inferior longitudinal fasciculus (ILF). SvPPA demonstrated focal left lateralized white matter degradation involving the uncinate fasciculus (UF) and anterior ILF, propagating to the right UF with disease progression. Conclusions: LvPPA and svPPA cohorts showed distinct longitudinal cognitive and white matter profiles. We propose differences in multi-centric and focal white matter dysfunction in lvPPA and svPPA, respectively, reflect underlying pathological differences. The clinical relevance of white matter degradation and mechanisms underlying disease propagation are discussed.

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“…Although several techniques to assess white matter development have been developed in addition to diffusion MR tractography (Ball et al., 2013; O'Muircheartaigh et al., 2014), advantages of diffusion tractography include the detection of three‐dimensional fiber bundle pathways. Many research studies have investigated white matter pathways in adults using diffusion tractography (Cercignani, Embleton, Parker, & Bozzali, 2012; Chao et al., 2009; Jin et al., 2011; Racine et al., 2014; Thong et al., 2014; Trojsi et al., 2013; Varentsova, Zhang, & Arfanakis, 2014). However, there have been far fewer studies on the development of pathways from birth to adult ages.…”

Section: Introductionmentioning

confidence: 99%

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Levman

Lim

et al. 2016

Brain and Behavior

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IntroductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time‐course of cerebellar peduncle pathways in pediatric and young adult subjects.MethodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion‐weighted measurements with high‐angular resolution diffusion imaging (HARDI) tractography.ResultsQualitative and quantitative results were analyzed for age‐based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were identified in vivo with this technique: pathways between the rostral pons and inferior‐lateral cerebellum (MCP cog), associated predominantly with higher cognitive function, and pathways between the caudal pons and superior‐medial cerebellum (MCP mot), associated predominantly with motor function.DiscussionOur findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

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Development of a high angular resolution diffusion imaging human brain template

Cited by 111 publications

References 42 publications

Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems

Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems

Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

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