Development of a High-Performance Anesthesia Ventilator for Research in Small Animals

Popoiu, Călin Marius; Burian, Caius Alexandru; Păunescu, Virgil; Boia, Eugen Sorin; Arghirescu, Smaranda; Muntean, Daniela-Lucia; Ordodi, Valentin

doi:10.5301/ijao.5000330

Cited by 2 publications

(2 citation statements)

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“…These models are used to analyze basic physiological mechanisms, for preclinical and toxicological studies and/or the evaluation of therapeutic approaches [1,2]. Rats are also useful model animals for studying acid-base balance, especially in relation to the cardiovascular and respiratory systems [1].…”

Section: Introductionmentioning

confidence: 99%

Chronobiology of Acid-Base Balance under General Anesthesia in Rat Model

Švorc¹

2018

Circadian Rhythm - Cellular and Molecular Mechanisms

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The design and development of experimental, in vivo, chronobiological animal models may help reveal some of the relationships between circadian rhythms and biological functions. In vivo experiments require the use of appropriate anesthesia, which should be selected according to their particular effect on the organism. The aim of study was to review the status of acid-base balance and ion concentration in arterial blood under common used general anesthesias in experiments in dependence on the light-dark (LD) cycle in spontaneously breathing rats. The experiments were performed using 3-to 4-monthold pentobarbital(P)-, ketamine/xylazine(K/X)-, and zoletil(Z)-anesthetized female Wistar rats after a 4-week adaptation to an LD cycle (12 h light and 12 h dark). We concluded that P anesthesia disturbs LD dependence of acid-base balance compared to K/X and Z anesthesia, but LD differences in plasma ion concentrations are disturbed under all type of general anesthesia. P anesthesia is not the most appropriate type of anesthesia in rat chronobiological experiments. It eliminated LD differences and also produces a more acidic environment, more pronounced hypercapnia and hypoxia than K/X and Z anesthesias. This should be taken into account because the altered internal environment may affect the activity of systems whose functions are primarily dependent on acid-base balance.

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Section: Introductionmentioning

confidence: 99%

Chronobiology of Acid-Base Balance under General Anesthesia in Rat Model

Švorc¹

2018

Circadian Rhythm - Cellular and Molecular Mechanisms

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show abstract

“…Currently, rat models are widely used not only because of their low costs but also for their ability to mimic several human pathologies. These models are used to analyze basic physiological mechanisms, for preclinical and toxicological studies, and/or the evaluation of therapeutic approaches [3,2] . Rats are also useful model animals for studying acidbase balance, especially in relation to the cardiovascular and respiratory systems [3] .…”

mentioning

confidence: 99%

Is Chronobiology of Internal Environment Important for “In Vivo” Rat Experiments?

Švorc¹

2018

JARPM

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Development of a High-Performance Anesthesia Ventilator for Research in Small Animals

Abstract: We describe the procedure for the manufacture of a reliable, high-performance anesthesia ventilator that facilitates recovery of spontaneous respiration at animal arousal with preservation of normal blood gases values and no damage to the lungs.

Cited by 2 publications

References 5 publications

Chronobiology of Acid-Base Balance under General Anesthesia in Rat Model

Chronobiology of Acid-Base Balance under General Anesthesia in Rat Model

Is Chronobiology of Internal Environment Important for “In Vivo” Rat Experiments?

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