Development of a High Performance Ion Chromatographic (HPIC) Method for the Determination of Sodium Metabisulfite in Parenteral Formulations

Abstract

A high performance i o n chromatographic (HPIC) method f o r the determination o f sodium m e t a b i s u l f i t e (a pharmaceutical antioxidant) i n i n j e c t a b l e formul a t i o n s i s described. The method i s selective f o r both the s u l f i t e and s u l f a t e ions w i t h a minimum o f sample preparation.

A Stability Indicating Method for the Determination of the Antioxidant Sodium Bisulfite in Pharmaceutical Formulation by RP-HPLC Technique

“…A detailed literature survey for SB revealed that a spectroscopic method is available for the determination of sulfite content in aqueous medium using Ellman’s reagent [ 4 ]. Another method allows for the determination of sodium metabisulfite in parenteral formulations by high performance ion chromatography [ 5 ]. In this technique, the correlation coefficient was found to be less (>0.99), the sample precision value was higher than 6.0 % and the stability-indicating capability of the method was not demonstrated according to ICH guidelines [ 6 ].…”