Development of a highly-sensitive acetylcholine sensor using a charge-transfer technique on a smart biochip

Lee, Seung-Ro; Rahman, Mohammed M.; Ishida, M.; Sawada, Kazuaki

doi:10.1016/j.trac.2008.11.009

Cited by 50 publications

(20 citation statements)

References 58 publications

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“…The number of pixels and their density have been increased: 32 × 32 pixels with a pitch of 130 μm, (29) 128 × 128 pixels with a pitch of 23 μm, (30) and 1024 × 1024 pixels with a pitch of 12.1 μm (31) have been reported. In addition to pH, the concentration of other ions such as K + (29) and Na + (32) and biomolecules such as acetylcholine (33,34) have been measured by modifying of the sensor area. A multimodal sensor, which simultaneously measures an optical image and a pH image, was also proposed.…”

Section: Ccd/cmos-based Ph Imaging Sensormentioning

confidence: 99%

“…Basic structures of (a) microelectrode array, (1)(2)(3) (b) BioLSI, (9) (c) ion-sensitive field-effect transistor, (13)(14)(15) and (d) CCD/CMOS-based pH imaging sensor. (33) (a) (b)…”

Section: Ccd/cmos-based Ph Imaging Sensormentioning

confidence: 99%

“…The visualization of acetylcholine with a CCD-based pH imaging sensor has also been reported. (33,34,77) …”

Section: Enzymatic Reactionmentioning

confidence: 99%

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Development and Bio-imaging Applications of a Chemical Imaging Sensor

2016

Sensors and Materials

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A chemical imaging sensor is a field-effect-based semiconductor sensor, capable of label-free imaging of ion distributions in a solution. The sensor has attracted much interest owing to its simple structure and diverse fields of application of bioimaging. In this article, the principle and development of the chemical imaging sensor are summarized, compared with those of other labelfree imaging sensors. Bio-imaging applications of the chemical imaging sensor to ion diffusion, enzymatic reaction, and metabolic activities of microorganisms are also reviewed.

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Section: Ccd/cmos-based Ph Imaging Sensormentioning

confidence: 99%

“…Basic structures of (a) microelectrode array, (1)(2)(3) (b) BioLSI, (9) (c) ion-sensitive field-effect transistor, (13)(14)(15) and (d) CCD/CMOS-based pH imaging sensor. (33) (a) (b)…”

Section: Ccd/cmos-based Ph Imaging Sensormentioning

confidence: 99%

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Development and Bio-imaging Applications of a Chemical Imaging Sensor

2016

Sensors and Materials

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“…As a result, it has been used for the detection of multiple ions due to its many ion-sensitive membranes [2,3]. However, many industrial and laboratory applications require the precise measurements of pH.…”

Section: Introductionmentioning

confidence: 99%

Temperature influence on pH-ISFET sensor operating in weak and moderate inversion regime: Model and circuitry

Naimi¹,

Hajji²,

Humenyuk

et al. 2014

Sensors and Actuators B: Chemical

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a b s t r a c tUsually most pH-ISFET readout circuits, with temperature compensation, were designed using transistors operating in strong regime. However, a classes of circuits elaborated with respect to MOS weak inversion are also very suitable for low-voltage and low-power applications. In this work, we discuss the problem of temperature variation at the sensor and circuit level. An analysis was made of the sensor operating in weak and moderate inversion regime. It has been shown that a simplified version of the EKV model combined with site-binding model can describe the behavior of ISFET toward the temperature and pH change. The experimental results agree very well with the analytical model for devices in large intervals of pH and temperature. Finally, the usage of model development is considered with an original concept of a readout circuit. The result of the simulation shows that the output signal is linear with pH, the design technique permits improving temperature insensitivity. The proposed circuit can be integrated with an ISFET by standard CMOS technology.

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“…Electro-chemical sensors can ideally fulill that goal by converting a chemical or biological response into a processable and quantiiable signal. In the past two decades, intensive research and development of electro-chemical sensors have enabled to fabricate diferent types of devices [22][23][24][25][26][27][28][29][30][31]. After the development of many successful commercial electro-chemical sensors in the classic conigurations, currently, there is a notable transition and increasing demands for the development of lexible and wearable sensors.…”

mentioning

confidence: 99%