2017
DOI: 10.1016/j.neuroimage.2017.06.008
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Development of a histologically validated segmentation protocol for the hippocampal body

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Cited by 15 publications
(23 citation statements)
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“…Given the above-mentioned contribution of different hippocampal subfields to brain function, imaging studies using non-invasive MRI techniques with anatomically adjusted hippocampal annotation may unravel still unobserved clinical-pathological correlations. In fact, several studies have employed automatic, semiautomatic, and manual segmentation techniques to evaluate volumetric changes in the hippocampal subfields in conditions such as Alzheimer's disease, post-traumatic stress disorder, schizophrenia, major depression, epilepsy, and aging ( 45 51 ). However, most techniques fail to properly delineate hippocampal subfields, which can induce misleading conclusions.…”
Section: Discussionmentioning
confidence: 99%
“…Given the above-mentioned contribution of different hippocampal subfields to brain function, imaging studies using non-invasive MRI techniques with anatomically adjusted hippocampal annotation may unravel still unobserved clinical-pathological correlations. In fact, several studies have employed automatic, semiautomatic, and manual segmentation techniques to evaluate volumetric changes in the hippocampal subfields in conditions such as Alzheimer's disease, post-traumatic stress disorder, schizophrenia, major depression, epilepsy, and aging ( 45 51 ). However, most techniques fail to properly delineate hippocampal subfields, which can induce misleading conclusions.…”
Section: Discussionmentioning
confidence: 99%
“…Aim : To determine the location of the borders of SUB/CA1, CA1/CA2, and CA2/CA3 relative to the length of the dark band in the hippocampal body, repeating the study by Steve et al ().…”
Section: Resultsmentioning
confidence: 99%
“…The freehand line tool in ImageJ (Schneider et al, ) was used to measure the length of the dark band, drawing a line through the midpoint of the dark band starting at the most medial point of the DG (inferior anchor point) and ending at the most superior medial point in the curvature of CA3 (superior anchor point; Figure b). Note that we chose to draw the line through the midpoint of the dark band, in contrast to Steve et al () who drew their line at the outer border of the SRLM on histology sections, as this boundary cannot be observed on MRI (see previous section). An advantage of using the midpoint is that the dark band is also visible on in vivo MRI, which would allow for in vivo application of this method in the future.…”
Section: Resultsmentioning
confidence: 99%
“…Hippocampal subfield segmentation is based on distinct histological differences which define the subfield boundaries (Ding & Van Hoesen, ; Duvernoy et al, ). As these histological features are not visible on MRI, segmentation protocols have been developed based on geometric rules derived from anatomical specimens with recent studies providing histological validation of some segmentation protocols (Steve et al, ). The majority of hippocampal segmentation protocols have been developed for the hippocampal body with the segmentation of the hippocampal head having been demonstrated to show the greatest disagreement among protocols (Yushkevich et al, ).…”
mentioning
confidence: 99%
“…The feasibility of applying a single common method of hippocampal subfield segmentation to the hippocampal head, body, and tail was assessed for Hippocampus 1. Subfield segmentation was performed on slices obtained with CMPR for the head, body, and tail based on our previously published manual protocol providing the following subfields: CA1, CA2, and CA3/CA4/dentate gyrus (Figure 6) (Steve et al, ).…”
mentioning
confidence: 99%