Development of a Lab-on-a-Chip Device for Rapid Nanotoxicity Assessment In Vitro

Shah, Pratikkumar

doi:10.25148/etd.fi15032160

Cited by 2 publications

(1 citation statement)

References 161 publications

(185 reference statements)

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“…Adding electrodes to cell-trapping microwells via metallic deposition followed by chemical etching allows for electrophoretic measurements of cell viability. A thesis by Pratikkumar [ 74 ] detailed a microfluidic device that incorporates a combination of dielectrophoresis (DEP) and microwell methods of trapping single cells in wells aligned with gold microelectrodes, which allowed for the analysis of cells using electrochemical methods. The DEP forces could be switched on and off during the cell capture step, allowing the targeted capture of specific cells on the individual electrode/well features.…”

Section: Microfluidics For Nanotoxicity Screeningmentioning

confidence: 99%

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

et al. 2017

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Many unique chemical compounds and nanomaterials are being developed, and each one requires a considerable range of in vitro and/or in vivo toxicity screening in order to evaluate their safety. The current methodology of in vitro toxicological screening on cells is based on well-plate assays that require time-consuming manual handling or expensive automation to gather enough meaningful toxicology data. Cost reduction; access to faster, more comprehensive toxicity data; and a robust platform capable of quantitative testing, will be essential in evaluating the safety of new chemicals and nanomaterials, and, at the same time, in securing the confidence of regulators and end-users. Microfluidic chips offer an alternative platform for toxicity screening that has the potential to transform both the rates and efficiency of nanomaterial testing, as reviewed here. The inherent advantages of microfluidic technologies offer high-throughput screening with small volumes of analytes, parallel analyses, and low-cost fabrication.

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Section: Microfluidics For Nanotoxicity Screeningmentioning

confidence: 99%

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

et al. 2017

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Nanotoxicity Assessment: A Necessity

Prabhakar

2020

NANOASIA

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Rapid growth of nanotechnology in various fields like medicine, diagnostics, biotechnology, electronics has gifted the world with products having extraordinary benefits. With increasing use of nanotechnology based products, there is a growing concern about toxicity associated with nanoparticles. Nano-size attributes unique properties to the material due to the increased surface area. But toxic effects associated with nanoparticles are also pronounced. Therefore, research in the field of nanotoxicology is of great importance. Some critical properties of nanoparticles such as chemical composition, size, shape, surface properties, purity are determinants of nanotoxicity. Thus, meticulous characterization of nanoparticles prior to toxicity assessment helps in reducing the toxicity by careful designing of nanoparticles. In vitro assessment of nanotoxicity involves testing on cultured cells whereas in vivo testing involves use of animal models like mice, rats, aquatic frogs etc. Use of predictive models like Zebrafish, Drosophila melanogaster for nanotoxicity research is increased in last few decades. Advanced methods for nanotoxicity assessment involve the use of electrochemical methods which can also give insights about mechanism of nanotoxicity. As the literature in this field is dispersed, this review collates various approaches to give a scheme for nanotoxicity evaluation right from the characterization to toxicity assessment.

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Development of a Lab-on-a-Chip Device for Rapid Nanotoxicity Assessment In Vitro

Cited by 2 publications

References 161 publications

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

Nanotoxicity Assessment: A Necessity

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