Development of a label-free SPR sensor for detection of matrixmetalloproteinase-9 by antibody immobilization on carboxymethyldextran chip

Mohseni, Sara; Moghadam, Tahereh Tohidi; Dabirmanesh, Bahareh; Jabbari, Safoura; Khajeh, Khosro

doi:10.1016/j.bios.2016.03.038

Cited by 60 publications

(27 citation statements)

References 42 publications

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“…A novel surface plasmon resonance (SPR) immunosensor of MMP-9 was recently reported ( Figure 10 ) [ 126 ]. One advantage of SPR immunosensor is that it allows real-time and label-free detection.…”

Section: Recent Advances In Mmp-9 Biosensor Researchmentioning

confidence: 99%

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Huang

2018

Sensors

540

365

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As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.

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Section: Recent Advances In Mmp-9 Biosensor Researchmentioning

confidence: 99%

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Huang

2018

Sensors

540

365

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“…Rapid and parallel detection in a single chip based on prism-configuration SPR and LSPR spectroscopy have been realized previously, but they always depend on complex and expensive components, which are not appropriate in practice for structure miniaturization. [18][19][20] In this paper, we proposed a dual-channel fiber-optic sensing probe based on two sensing structures with different modulation methods (intensity and wavelength interrogation). Two unclad portions of the fiber probe are coated with gold nanoparticles (GNPs) and a sandwich configuration of Au/indium tin oxide (ITO)/Au film, respectively.…”

Section: Introductionmentioning

confidence: 99%

Dual-channel fiber surface plasmon resonance biological sensor based on a hybrid interrogation of intensity and wavelength modulation

Zhang

Liang

et al. 2016

J. Biomed. Opt

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We investigate an intensity and wavelength modulation combined plasmon resonance-based fiber-optic sensor technology. Composed of gold nanoparticles (GNPs) and sandwich configuration of Au/indium tin oxide (ITO)/Au film, two sensing regions are fabricated separately along with unclad portions of the fiber-optic probe. It can simultaneously monitor both the light intensity from the Au NP channel and the wavelength from the Au/ITO/Au film channel with a single detector. As the refractive index (RI) of the external environment changes, the transmission intensity and resonance wavelength in the two channels are modified, which provides an interrogation of intensity and wavelength modulation. The sandwich film structure is formed using magnetron sputtering technology, and the GNPs functioning as localized surface plasmon resonators are coated on a multimode optical fiber via the layer-by-layer method. The experimental results reveal that the RI sensitivities of the two sensing channels are 334.1% RIU?1 and 1963.2??nm/RIU, respectively. Based on the above sensing design, we conduct real-time and label-free monitoring of IgG/anti-IgG and Con A/RNase B biomolecular interaction. The resonant dips excited by different sensing modes make it more attractive as a multichannel surface plasmon resonance analysis technology, which is valuable in biological and life sciences research and rapid diagnostics.

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“…Taking advantage of PSPR and LSPR-based analytical methods has created extensive applications in the development of immunoassays for diagnosing diseases with protein biomarkers [26,27]. Mohseni et al have reported on the development of SPR-based immunosensors for real-time and label-free detection of recombinant human matrix metalloproteinases-9 (MMP-9) as a biomarker for malignant tumor progression and metastasis [28] ( Figure 1a). A carboxymethyl dextran hydrogel sensor chip was utilized for the immobilization of anti-MMP-9 monoclonal antibodies through amine coupling reagents and further experiments.…”

Section: Analytical Methods For Protein Biomarkersmentioning

confidence: 99%

Noble Metal-Assisted Surface Plasmon Resonance Immunosensors

Choi

Lee

Son

et al. 2020

Sensors

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For the early diagnosis of several diseases, various biomarkers have been discovered and utilized through the measurement of concentrations in body fluids such as blood, urine, and saliva. The most representative analytical method for biomarker detection is an immunosensor, which exploits the specific antigen-antibody immunoreaction. Among diverse analytical methods, surface plasmon resonance (SPR)-based immunosensors are emerging as a potential detection platform due to high sensitivity, selectivity, and intuitive features. Particularly, SPR-based immunosensors could detect biomarkers without labeling of a specific detection probe, as typical immunosensors such as enzyme-linked immunosorbent assay (ELISA) use enzymes like horseradish peroxidase (HRP). In this review, SPR-based immunosensors utilizing noble metals such as Au and Ag as SPR-inducing factors for the measurement of different types of protein biomarkers, including viruses, microbes, and extracellular vesicles (EV), are briefly introduced.

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Development of a label-free SPR sensor for detection of matrixmetalloproteinase-9 by antibody immobilization on carboxymethyldextran chip

Cited by 60 publications

References 42 publications

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Dual-channel fiber surface plasmon resonance biological sensor based on a hybrid interrogation of intensity and wavelength modulation

Noble Metal-Assisted Surface Plasmon Resonance Immunosensors

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