Development of a Liquid‐Liquid Biphasic Reaction Using a Taylor Vortex Flow Reactor

Abstract

This paper describes a liquid-liquid biphasic flow reaction system that is simple to control. In a liquid-liquid biphasic flow reaction, the slug-flow in the tube reactors generally improves the reaction rate. However, we show that larger tube diameters decreased the reaction rate and the formation of the slug-flow was influenced by the tube diameter, the size of the mixer, and the pump mechanism. These results indicated that technical difficulties with the slug-flow could be an obstacle to scale-up. To resolve this problem, we suggest the use of a Taylor vortex flow reactor to achieve a higher reaction rate than with batch and slugflow systems.

Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors

“…In our previous work, the reaction rate in a Taylor vortex flow reactor was superior to that in a batch reactor. 8 The difference between the present work and our previous one can be explained by the difference of concentrations. To compare the size of droplets generated by mixing biphasic reaction solutions, images were taken with a high-speed camera (Figure 3).…”

“… a Reaction solution was quenched by 10 wt % HCl aq., then the organic phase was analyzed. b Conv = (area % of 2 )/[(area % of 1 ) × 3.302 + (area % of 2 )] × 100. 3.302: response factor in HPLC. c This experimental data was extracted from entry 1 in Table in ref . …”

“…7 We previously reported the application of a flow reaction to a liquid−liquid biphasic alkylation using a Taylor vortex flow reactor (Figure 1). 8 This methodology suggested how to improve mixing efficiency over that of a conventional slug flow system and led to a practical flow system appropriate for scaleup. Taylor vortices generated by the rotation axis are based on active mixing and strengthen the mixing efficiency independent of the flow rate unlike the passive mixing by a static mixer.…”

“…We previously reported the application of a flow reaction to a liquid–liquid biphasic alkylation using a Taylor vortex flow reactor (Figure ). This methodology suggested how to improve mixing efficiency over that of a conventional slug flow system and led to a practical flow system appropriate for scale-up. Taylor vortices generated by the rotation axis are based on active mixing and strengthen the mixing efficiency independent of the flow rate unlike the passive mixing by a static mixer. − A Taylor vortex flow reactor consists of only a cylindrical tube and a rotation axis, making it easy to clean; this is an essential factor for manufacturing active pharmaceutical ingredients (APIs) under good manufacturing practice .…”

Study on Flow Characteristics and Mass Transfer Mechanism of Kettle Taylor Flow Reactor

“…In this paper, the Taylor vortex is introduced into a stirred tank reactor to improve the flow and mass transfer characteristics of the reactor by designing a scheme of a gas-liquid mixed jet. The Taylor vortex is a fluid motion existing between two coaxial cylinder annulus; a series of axial alternating and orderly secondary vortices are generated between the annulus through the relative rotation of the inner and outer cylinders [6]. The basic structure of the conventional Taylor flow reactor is shown in Figure 1.…”