Development of a magnetic lab-on-a-chip for point-of-care sepsis diagnosis

Schotter, Joerg; Shoshi, Astrit; Brueckl, Hubert

doi:10.1016/j.jmmm.2009.02.111

Cited by 25 publications

(13 citation statements)

References 15 publications

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“…A prototype of magnetic lab-on-a-chip for point-of-care sepsis diagnosis was recently reported [11]. Various applications of magnetism in microfluidic areas were introduced by Pamme [12].…”

Section: Introductionmentioning

confidence: 99%

Motion of paramagnetic particles in a viscous fluid under a uniform magnetic field: benchmark solutions

Suh

Kang

2010

J Eng Math

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Numerical simulations of the two-dimensional motion of multiple paramagnetic particles suspended in a viscous fluid subjected to a uniform magnetic field are presented. Both the magnetic field and flow field can be described efficiently with simple series in local coordinates attached to each particle. The coefficients of the series can be obtained with fast convergence when only a few leading coefficients are treated implicitly. Numerical results for the flow field are validated by comparing the data with those given by an asymptotic solution for a pair of particles separated by a small distance. The numerical results of the magnetic field are validated by comparison with the solutions in bipolar coordinates. Simulations of the motion of multiple particles reveal interesting phenomena and shed light on the fundamental mechanism of particles clustering into a straight chain. The data presented in this paper can be used as a benchmark solution for verifying codes for simulating the motion of paramagnetic particles in a magnetic field.

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“…A prototype of magnetic lab-on-a-chip for point-of-care sepsis diagnosis was recently reported [11]. Various applications of magnetism in microfluidic areas were introduced by Pamme [12].…”

Section: Introductionmentioning

confidence: 99%

Motion of paramagnetic particles in a viscous fluid under a uniform magnetic field: benchmark solutions

Suh

Kang

2010

J Eng Math

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“…A detection limit for human IgG antigen of 70 pmol L −1 was reported, but lower detection limits were noted as possible by integration of the micro Hall sensor previously discussed. Schotter et al have shown that integration of a magnetoresistive sensor and magnetic capture immunoassay (meander MET) in a microchannel results in a sensitive and automated point-of-care system capable of detection of four different sepsis-indicative cytokines from a 5-μL sample of blood [58].…”

Section: Met Sensorsmentioning

confidence: 99%

Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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Microelectromagnetic traps (METs) have been used for almost two decades to manipulate magnetic fields. Different trap geometries have been shown to produce distinct magnetic fields and field gradients. Initially, microelectromagnetic traps were used mainly to separate and concentrate magnetic material at small scales. Recently such traps have been implemented for unique applications, for example filterless bioseparations, inductive heat generation, and biological detection. In this review, we describe recent reports in which MET geometry, current density, or external fields have been used. Descriptions of recent applications in which METs have been used to develop sensors, manipulate DNA, or block ion current are also provided.

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“…Another requirement for the design of such an LOC system needs a more fundamental discussion on the detection of analyte molecules in terms of physical quantities. Independent of the detection method used to quantify the analyte molecules (e.g., fluorescence detection (FD), magnetoresistive detection (MD), reflected electromagnetic radiation for surface plasmon resonance displacement detection (SPR)) [ 6 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], the detector read out signal is always related to a density of the physical quantity to be measured. For FD this is the fluorescence intensity impinging on the detector surface which is proportional to the emitted fluorescence intensity of the source volume, for MD this is the magnetic flux density of analyte loaded superparamagnetic beads immobilized above the sensor area, and for SPR this is the change in the optical refraction index averaged over the volume close to the metal layers due to the binding of analyte molecules to immobilized capture molecules above an organic matrix.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications

Ehresmann

Koch

Holzinger

2015

Sensors

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A technology platform based on a remotely controlled and stepwise transport of an array arrangement of superparamagnetic beads (SPB) for efficient molecular uptake, delivery and accumulation in the context of highly specific and sensitive analyte molecule detection for the application in lab-on-a-chip devices is presented. The near-surface transport of SPBs is realized via the dynamic transformation of the SPBs’ magnetic potential energy landscape above a magnetically stripe patterned Exchange-Bias (EB) thin film layer systems due to the application of sub-mT external magnetic field pulses. In this concept, the SPB velocity is dramatically influenced by the magnitude and gradient of the magnetic field landscape (MFL) above the magnetically stripe patterned EB substrate, the SPB to substrate distance, the magnetic properties of both the SPBs and the EB layer system, respectively, as well as by the properties of the external magnetic field pulses and the surrounding fluid. The focus of this review is laid on the specific MFL design in EB layer systems via light-ion bombardment induced magnetic patterning (IBMP). A numerical approach is introduced for the theoretical description of the MFL in comparison to experimental characterization via scanning Hall probe microscopy. The SPB transport mechanism will be outlined in terms of the dynamic interplay between the EB substrate’s MFL and the pulse scheme of the external magnetic field.

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Development of a magnetic lab-on-a-chip for point-of-care sepsis diagnosis

Cited by 25 publications

References 15 publications

Motion of paramagnetic particles in a viscous fluid under a uniform magnetic field: benchmark solutions

Motion of paramagnetic particles in a viscous fluid under a uniform magnetic field: benchmark solutions

Applications of microelectromagnetic traps

Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications

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