Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations

Shirvalilou, Sakine; Khoei, Samideh; Khoee, Sepideh; Raoufi, Nida Jamali; Karimi, Mohammad Reza; Shakeri‐Zadeh, Ali

doi:10.1016/j.cbi.2018.08.027

Cited by 88 publications

(43 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Figure 11mentioning

confidence: 84%

“…The saturation magnetization was 15.98 emu/g. Treatment with IUdR/GO/SPION/PLGA and external magnetic field caused a reduction in cancer volume in rats compared to buffered saline, IudR, and SPION/IUdR/NGO/PLGA-treated rats [169]. CPT loaded to doubly decorated MSNs grafted with fluorescent conjugates, coated with polydopamine (PDA) and GO layers, was investigated by Tran et al, in relation to targeted delivery and controlled release.…”

Section: Figure 11mentioning

confidence: 99%

See 1 more Smart Citation

Graphenic Materials for Biomedical Applications

2019

View full text Add to dashboard Cite

Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

show abstract

Section: Figure 11mentioning

confidence: 84%

Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

View full text Add to dashboard Cite

show abstract

“…Sixth, magnetic targeting is an interesting concept, which relies on the application of a magnetic field directly on magnetic anti-GBM drugs, to trigger the diffusion of these drugs towards the tumor. Although this approach has shown some efficacy on small animals (e.g., magnetic anti-GBM drugs accumulated in rat glioblastoma following the application of a 0.5 T magnetic field [78]), its translation for human applications faces certain difficulties. On the one hand, equipment that generates a sufficiently strong and precise magnetic field gradient to trigger the diffusion of anti-GBM drugs towards tumors is currently lacking.…”

Section: Nano-drugs Improve Gbm Drug Deliverymentioning

confidence: 99%

Nano-Therapies for Glioblastoma Treatment

Alphandéry

2020

Cancers

View full text Add to dashboard Cite

Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., Treg cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.

show abstract

“…53 Shirvalilou et al developed magnetic NGO as a drug carrier for improving gliomatargeted iodo-2-deoxyuridine (IUdR) delivery and imaging. 54 By conducting RNA-Seq analysis and following IPA analysis, the top 10 upregulated and top 10 downregulated molecules after GO-PEG-erlotinib treatment on NPC cells were identified (Table 1). Some of these molecules have been reported to be associated with carcinogenesis and prognosis in other types of cancers.…”

Section: Dovepressmentioning

confidence: 99%

<p>Polyethylene Glycol-Coated Graphene Oxide Loaded with Erlotinib as an Effective Therapeutic Agent for Treating Nasopharyngeal Cancer Cells</p>

Lan

Hsu

Lan

et al. 2020

IJN

View full text Add to dashboard Cite

Introduction: Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Taiwan, and radiation therapy combined with or without chemotherapy is its mainstay treatment. Although it is highly sensitive to radiotherapy, local recurrence and distant metastasis remain difficult unsolved problems. In recent years, graphene oxide (GO) has been found to be a promising novel anticancer drug carrier. Here, we present our designed functionalized GO, polyethylene glycol-coated GO (GO-PEG), as a drug carrier, which was loaded with erlotinib and showed promising anticancer effects on NPC cells. Methods: The effects of GO-PEG-erlotinib on the proliferation, migration, and invasion of NPC cells were investigated by WST-8 assay, wound healing assay, and invasion assay, respectively. RNA sequencing was conducted and analyzed to determine the molecular mechanisms by which GO-PEG-erlotinib affects NPC cells. Results: Our results showed that GO-PEG-erlotinib reduced NPC cell viability in a dosedependent manner and also inhibited the migration and invasion of NPC cells. The RNA sequencing revealed several related molecular mechanisms. Conclusion: GO-PEG-erlotinib effectively suppressed NPC cell proliferation, migration, and invasion, likely by several mechanisms. GO-PEG-erlotinib may be a potential therapeutic agent for treating NPC in the future.

show abstract

Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations

Cited by 88 publications

References 39 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Nano-Therapies for Glioblastoma Treatment

<p>Polyethylene Glycol-Coated Graphene Oxide Loaded with Erlotinib as an Effective Therapeutic Agent for Treating Nasopharyngeal Cancer Cells</p>

Contact Info

Product

Resources

About