Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications

Kasper, Mary; Ellenbogen, Bret; Hardy, R. A.; Cydis, Madison; Mojica-Santiago, Jorge; Afridi, Abdullah; Spearman, Benjamin S.; Singh, Isha; Kuliasha, Cary A.; Atkinson, Eric W.; Otto, Kevin J.; Judy, Jack W.; Rinaldi‐Ramos, Carlos M.; Schmidt, Christine E.

doi:10.1016/j.biomaterials.2021.121212

Cited by 26 publications

(32 citation statements)

References 69 publications

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“…Modulation of hydrogels stiffness has also been explored as an approach to develop mechanically matching electronic nerve interfaces for tissue regeneration. Schwann cell proliferation was compared among magnetically templated glycidyl methacrylate hyaluronic acid hydrogels with different stiffnesses 159 . The hydrogels with mechanical properties similar to fresh nerve tissue promoted cell migration and infiltration within the scaffolds.…”

Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

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Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and long lasting IMDs. This review gives an overview of FBR as well as anti‐FBR strategies. Furthermore, we highlight recent advances in biomimetic approaches to resist FBR, focusing on their characteristics and potential biomedical applications.

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Section: Implant Properties Affect the Degree Of Host Responsementioning

confidence: 99%

Advanced strategies to thwart foreign body response to implantable devices

Capuani

Malgir

Chua

et al. 2022

Bioengineering & Transla Med

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“…Promoting nerve regeneration and transmitting electrophysiological signals are two important aspects for the repair of peripheral nerve defects ( Zhao et al, 2020 ; Kasper et al, 2021 ; Kunisaki et al, 2021 ). The fabricated MXene-PCL NGC by electrospinning could provide suitable mechanical support, affording a necessary lumen for nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…Biodegradable materials, such as polycaprolactone, chitosan, and polylactic acid, are used to fabricate NGCs in many studies ( Barroca et al, 2018 ; Qian et al, 2020 ; Sun et al, 2021 ; Zeng et al, 2021 ). Electrical signals play an important role in normal nerve function and nerve regeneration ( Qian et al, 2019 ; Qian et al, 2020 ; Wang et al, 2020 ; Kasper et al, 2021 ). The conductive NGC is a promising substitute for autograft in repairing PNI ( Zhang et al, 2020 ; Zhao et al, 2020 ; Jin et al, 2021 ; Song et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Nan

Lin

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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An electrical signal is the key basis of normal physiological function of the nerve, and the stimulation of the electric signal also plays a very special role in the repair process of nerve injury. Electric stimulation is shown to be effective in promoting axonal regeneration and myelination, thereby promoting nerve injury repair. At present, it is considered that electric conduction recovery is a key aspect of regeneration and repair of long nerve defects. Conductive neural scaffolds have attracted more and more attention due to their similar electrical properties and good biocompatibility with normal nerves. Herein, PCL and MXene-PCL nerve guidance conduits (NGCs) were prepared; their effect on nerve regeneration was evaluated in vitro and in vivo. The results show that the NGCs have good biocompatibility in vitro. Furthermore, a sciatic nerve defect model (15 mm) of SD rats was made, and then the fabricated NGCs were implanted. MXene-PCL NGCs show similar results with the autograft in the sciatic function index, electrophysiological examination, angiogenesis, and morphological nerve regeneration. It is possible that the conductive MXene-PCL NGC could transmit physiological neural electric signals, induce angiogenesis, and stimulate nerve regeneration. This paper presents a novel design of MXene-PCL NGC that could transmit self-originated electric stimulation. In the future, it can be combined with other features to promote nerve regeneration.

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“…To verify the effect of a magnetic composite material in vivo, researchers in one study produced a magnetically aligned regenerative tissue-engineered electronic nerve interface (MARTEENI) and implanted it within a rat sciatic-nerve transection model. It was found that the interface promoted the growth of nerve axons [ 83 ].…”

Section: Application Of Magnetic Composite Biomaterials In Peripheral...mentioning

confidence: 99%

Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair

et al. 2022

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Peripheral nerve injury (PNI) is a clinical problem with high morbidity that can cause severe damage. Surgical suturing or implants are usually required due to the slow speed and numerous factors affecting repair after PNI. An autologous nerve graft is the gold standard for PNI repair among implants. However, there is a potential problem of the functional loss of the donor site. Therefore, tissue-engineered nerve biomaterials are often used to bridge the gap between nerve defects, but the therapeutic effect is insufficient. In order to enhance the repair effect of nerve biomaterials for PNI, researchers are seeking to combine various stimulation elements, such as the addition of biological factors such as nerve growth factors or physical factors such as internal microstructural modifications of catheters and their combined application with physical stimulation therapy. Physical stimulation therapy is safer, is more convenient, and has more practical features than other additive factors. Its feasibility and convenience, when combined with nerve biomaterials, provide broader application prospects for PNI repair, and has therefore become a research hot spot. This paper will review the combined application of physical stimulation and biomaterials in PNI repair in recent years to provide new therapeutic ideas for the future use of physical stimulation in PNI repair.

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Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications

Cited by 26 publications

References 69 publications

Advanced strategies to thwart foreign body response to implantable devices

Advanced strategies to thwart foreign body response to implantable devices

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair

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