Development of a micro biochip integrated traveling wave micropumps and surface plasmon resonance imaging sensors

Abstract

Since most of miniaturized surface plasmon resonance (SPR) sensing systems need commercially available peristaltic or syringe pumps, it is difficult to reduce the system size, biosample volume, and the production cost. In this paper, a compact biochip for clinical diagnosis is presented. The proposed biochip is integrated traveling wave micropumps and SPR imaging sensors on one chip. The micropump is composed of flexible microchannel and piezoelectric bimorph actuator array, and achieved the maximum flow rate 336 ll/min. The SPR imaging biosensor can quantitatively measure biosamples with multi microchannels, i.e. one biosample and two reference flows to obtain an analytical curve. The SPR imaging measurements with bovine serum albumin solutions were carried out using the prototype of the proposed diagnostic system composed of a pair of the micropump and the sensor. Since the clear SPR signal curve was observed, it was confirmed that the proposed system can be applicable to the clinical diagnosis.

Deformation of PDMS membrane and microcantilever by a water droplet: Comparison between Mooney–Rivlin and linear elastic constitutive models

“…The model has an applicable strain of about 100% in tension and 30% in compression. Then, the constitutive equation for hyperelastic incompressible materials can be expressed as: (6) where σ is the Cauchy stress tensor, and p is the hydrostatic pressure.…”

“…(3) easily fabricated, it has been widely used in lab-on-a-chip [1][2][3][4][5][6] and some microfluidic devices [7][8][9][10][11][12][13], etc.…”

Self-aligned fabrication process for active membrane in magnetically driven micropump using photosensitive composite

“…Micro total analysis systems (µTAS) integrated with microdevices on a chip have been studied for medical testing and chemical analysis processes [1][2][3]. As a µTAS enables us to achieve fast detection, low consumption of sample, and small dimension systems, microdevices (micropumps, microvalves, micromixers, etc) were developed for the further utilisation and optimisation of µTAS [4][5][6][7][8][9]. In the microdevices, an active membrane performs an important role to achieve fluid control, elastic deformation, and volume change in a micro chamber.…”