Development of a mild mercaptoethanol extraction method for determination of mercury species in biological samples by HPLC–ICP-MS

Microwave-assisted Extraction and Ion Chromatography Dynamic Reaction Cell Inductively Coupled Plasma Mass Spectrometry for the Speciation Analysis of Arsenic and Selenium in Cereals

“…Coupling of LC to ICP-MS gained much attention due to its easiness of sample preparation, simplicity of the interface to the detector, availability of isotope ratio information and specificity of the signal intensity of the determined element. 17 Moreover, the use of LC will enable the separation of more species of As and Se in a single run. The determination of selenium by quadrupole ICP-MS is typically compromised by isobaric interferences from 40 Ar 40 Ar + on 80 Se + and 40 Ar 38 Ar + on 78 Se + .…”

Determination of mercury species in foodstuffs using LC-ICP-MS: the applicability and limitations of the method

“…In order to liberate the mercury species from the biological matrices investigated in this work, an extraction with hydrochloric acid-2-ME solution (procedure A) was applied. The selection of the extractant came from the preceding analogous application of diluted acids (Westöö 1966;Kratzer et al 1994;Margentínová et al 2008;Reyes et al 2009) or solutions of thiol compounds (Hight & Cheng 2006;Wang et al 2007). A strongly acidic medium enables to liberate mercury species from a solid matrix.…”

“…Mobile phases usually contain some thiol compounds, most commonly 2-mercaptoethanol (Huang & Jiang 1993;Ramalhosa et al 2001;Vidler et al 2007;Lin et al 2008;Weiyue et al 2011), cysteine (Wan et al 1997;Hight & Cheng 2006;Percy et al 2007;Vallant et al 2007;Sannac et al 2009) or both these compounds (Chiou 2001;Rodrigues et al 2010). The thiol compounds are also used as components of extractants to isolate mercury species from solid samples (Chiou et al 2001;Hight & Cheng 2006;Wang et al 2007;Sannac et al 2009;Rodrigues et al 2010;de Souza et al 2010;Weiyue et al 2011). The addition of a thiol compound results in a formation of thiolates or chelates of mercury species with an Hg-S bond.…”

Application of Organometallic Speciation in Clinical Studies

“…Coupling HPLC with ICP-MS is one of the most versatile means to perform Hg speciation analysis since both liquid and gaseous sample introduction are acceptable for ICP-MS. If liquid samples are to be introduced directly into ICP-MS, coupling of HPLC with ICP-MS is straightforward by just connecting the outlet of the HPLC column to the nebulizer of the ICP-MS with a PTFE coil [161,162]. Normally, in this case a cooled spray chamber and a postnebulization oxygen addition are required to limit the solvent loading on the plasma, which will lead to quenching of the plasma, and reduce carbon condensation on the cones.…”