Development of a Molecularly Imprinted Polymer-Based Sensor for the Electrochemical Determination of Triacetone Triperoxide (TATP)

Mamo, Samuel; Gonzalez-Rodriguez, Jose

doi:10.3390/s141223269

Cited by 48 publications

(34 citation statements)

References 18 publications

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“…Electrochemical template removal [41] was performed by immersing the polymer-modified electrode in 0.1 M H 2 SO 4 and cycling the potential between -0.2 and 1.5 V at 200 mV/s and the CV of 10 mM K 4 Fe(CN) 6 was obtained intermittently to monitor the progression of the template removal. A sudden increase in the peak current was observed between 30 and 40 removal cycles indicating the necessity to perform at least 40 cycles to quantitatively remove the template (Figure 3a).…”

Section: Template Removalmentioning

confidence: 99%

Electrosynthesized molecularly imprinted polyscopoletin nanofilms for human serum albumin detection

Stojanović

Erdőssy

Keltai

et al. 2017

Analytica Chimica Acta

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Molecularly imprinted polymers (MIPs) rendered selective solely by the imprinting with protein templates lacking of distinctive properties to facilitate strong target-MIP interaction are likely to exhibit medium to low template binding affinities. While this prohibits the use of such MIPs for applications requiring the assessment of very low template concentrations, their implementation for the quantification of high-abundance proteins seems to have a clear niche in the analytical practice. We investigated this opportunity by developing a polyscopoletin-based MIP nanofilm for the electrochemical determination of elevated human serum albumin (HSA) in urine. As reference for low abundance protein ferritin-MIPs were 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 also prepared by the same procedure. Under optimal conditions, the imprinted sensors gave a linear response to HSA in the concentration range of 20-100 mg/dm 3 , and to ferritin in the range of 120-360 mg/dm 3 . While as expected the obtained limit of detection was not sufficient to determine endogenous ferritin in plasma, the HSA-sensor was successfully employed to analyse urine samples of patients with albuminuria. The results suggest that MIP-based sensors may be applicable for quantifying high abundance proteins in a clinical setting.

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Section: Template Removalmentioning

confidence: 99%

Electrosynthesized molecularly imprinted polyscopoletin nanofilms for human serum albumin detection

Stojanović

Erdőssy

Keltai

et al. 2017

Analytica Chimica Acta

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“…GCEs, which have lower porosity and higher mechanical rigidity than CPEs, have been also modified with explosives imprinted polymers using a range of different methodologies by different research groups [26,27,46,48,52].…”

Section: Sensorsmentioning

confidence: 99%

Molecularly Imprinted Polymer Materials as Selective Recognition Sorbents for Explosives: A Review

et al. 2019

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Explosives are of significant interest to homeland security departments and forensic investigations. Fast, sensitive and selective detection of these chemicals is of great concern for security purposes as well as for triage and decontamination in contaminated areas. To this end, selective sorbents with fast binding kinetics and high binding capacity, either in combination with a sensor transducer or a sampling/sample-preparation method, are required. Molecularly imprinted polymers (MIPs) show promise as cost-effective and rugged artificial selective sorbents, which have a wide variety of applications. This manuscript reviews the innovative strategies developed in 57 manuscripts (published from 2006 to 2019) to use MIP materials for explosives. To the best of our knowledge, there are currently no commercially available MIP-modified sensors or sample preparation methods for explosives in the market. We believe that this review provides information to give insight into the future prospects and potential commercialization of such materials. We warn the readers of the hazards of working with explosives.

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“…Chemical sensors [67][68][69][70][71][72][73][74][75][76][77][78][79] and optical sensors remain a potential technology used for the detection of hazard materials for a host of reasons including that they are reproducible, and can be manufactured to be low cost, portable, and can be fabricated to be target specific. Generally, in a chemical sensor, some chemical undergoes a selective reaction once it comes into contact with a target explosive material.…”

Section: Brief Review Of Some Current Techniques Utilized For the Detmentioning

confidence: 99%

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

2015

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Generally the fabrication, assembly and evaluation of plasmonic nanostructures for surface enhanced Raman scattering (SERS) substrates has focused on static rigid substrates such as glass and silicon. However, these static substrates severely limit the application of plasmonic nanostructures as (i) they provide no means to alter the state of assembly of the nanostructures once they are formed or anchored on the surface i.e., not reconfigurable; and (ii) preclude applications which demand non-planar, flexible or conformal surfaces. The above considerations has led to the development of a novel class of SERS substrates based on flexible substrates such paper, polymer membranes and electrospun fibers. These flexible SERS media based on unconventional substrates such as paper offer distinct advantages compared to the conventional SERS substrates in that (i) flexible nature of the substrate enables conformal contact with the surfaces under investigation leading to efficient sample collection; (ii) porous nature of the SERS substrate (interstices between the fibers) provides efficient access to the analytes; (iii) high surface area of the 3D paper substrate results in large dynamic range of the chemical sensors; (iv) intricate network of fibers decorated with metal nanoparticles can provide potentially high density of electromagnetic hotspots; (v) intense light scattering caused by the fibrous structure of the substrate (e.g., paper) enables efficient light-metal interaction; and (vi) facile fabrication leads to efficient, robust, reliable, reusable and cost-effective SERS substrates. In this presentation, we will focus on the Army need for a more flexible (substrate surface and application) SERS substrate for universal sensing. This presentation will leverage from material presented at a flexible SERS (May 2014) workshop hosted by Dr. Srikanth Singamaneni at Washington University.

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Development of a Molecularly Imprinted Polymer-Based Sensor for the Electrochemical Determination of Triacetone Triperoxide (TATP)

Cited by 48 publications

References 18 publications

Electrosynthesized molecularly imprinted polyscopoletin nanofilms for human serum albumin detection

Electrosynthesized molecularly imprinted polyscopoletin nanofilms for human serum albumin detection

Molecularly Imprinted Polymer Materials as Selective Recognition Sorbents for Explosives: A Review

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

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