Development of a molecularly imprinted polymer for selective extraction of bisphenol A in water samples

Abstract

A cross-linked methacrylate molecularly imprinted polymer (poly-4-vinylpyridine-co-trimethylolpropane-trimethacrylate) selective for bisphenol A (BPA) was synthesized, using a fluorinated BPA derivative (4,4'-(hexafluoroisopropylidene)-diphenol) as a mimic template, and applied to the analysis of real-world samples of process and potable waters. The molecularly imprinted polymer also showed a high affinity and selectivity for 17-beta-estradiol and ethynylestradiol. A method to analyze BPA, 17-beta-estradiol, and ethynylestradiol at ultratrace levels was thus developed from a screening procedure to monitor endocrine-disrupting chemicals in water samples. The method consists of the BPA-selective cleanup by molecularly imprinted SPE using cartridges packed with the polymer developed, its recovery by stir bar sorptive extraction after ad hoc derivatization to obtain the corresponding BPA-acetate, and its analysis by GC-time window-SIM-MS after online thermal desorption. The method showed good linearity in the working range (R(2)=0.9969), high repeatability (RSD% <10.1), recoveries always above 90%, and very low LOD (10 pg/L) and LOQ (1 ng/L) and can easily be extended to the determination of 17-beta-estradiol and ethynylestradiol ultratraces. The method's effectiveness was evaluated by analyzing the real-world water samples; it enabled preconcentration and detection of BPA at ultratrace levels.

Small‐Molecule Dengue Virus Co‐imprinting and Its Application as an Electrochemical Sensor

“…The efficiencies of MIP composites sensors prepared using dengue virus with BPA and without will be investigated in terms of substrate recognition. Available data on the use of MIPs based sensors to detect BPA has been used to compare to the results from this work . LOD by a virus assisted MCIP sensor determined here to detect BPA was lower than LOD from other MIPs based methods.…”

“…Available data on the use of MIPs based sensors to detect BPAh as been used to compare to the results from this work. [26][27][28] LOD by av irus assisted MCIP sensor determined here to detectB PA was lower than LOD from other MIPs based methods.…”

Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis

“…Canale et al [82] packed BPA-MIPs into monolithic column and installed it on an HPLC unit for the determination of BPA in realworld water samples. The monolithic column exhibited good selectivity and concentration capability in the analysis of BPA in water samples.…”

Pre‐concentration of trace amount of bisphenol A in water samples by palm leaf ash and determination with high‐performance liquid chromatography

“…Recently, endocrine disturbing chemicals have been identified as the most notorious contaminants (Canale et al, 2010;Jing et al, 2011;Cai et al, 2004). Recently, endocrine disturbing chemicals have been identified as the most notorious contaminants (Canale et al, 2010;Jing et al, 2011;Cai et al, 2004).…”

“…There are several methods for sample preparation, such as microwave-assisted extraction (Pedersen and Lindholst, 1999), liquid-liquid extraction (LLE) (Helaleh et al, 2001), solid-phase microextraction (SPME) (Sanagi et al, 2015;Ali et al, 2008), liquid phase microextraction (LPME) (Basheer and Lee, 2004), molecularly imprinted solid-phase extraction (Canale et al, 2010;Ali, 2009), dispersive liquid-liquid microextraction (DLLME) (Rezaee et al, 2009) and solid-phase extraction (SPE). Among these methods, LLE is an exhaustive traditional preparation technique used to extract and preconcentrate different analytes from environmental water samples.…”