Development of a more efficient catalyst for the redox-neutral organocatalytic mitsunobu reaction by DFT-guided catalyst design

Asymmetric Total Synthesis of Anti-HBV Drug Entecavir: Catalytic Strategies for the Stereospecific Construction of Densely Substituted Cyclopentene Cores

“…Our retrosynthetic analysis of entecavir ( 1 ) is outlined in Scheme . We intended to assemble the purine nucleobase at a later stage via a Mitsunobu reaction, utilizing the highly congested cyclopentene core 6 containing three stereogenic centers and an exocyclic double bond. The crucial chiral carbocyclic scaffold 6 would be established through a stereoselective borylative cyclization , of 1,6-enyne 7 , followed by oxidation and protecting groups conversion.…”