The Mine-to-Mill (M2M) approach aims to enhance efficiency and reduce costs in the mineral processing industry by optimizing the mining and processing stages. M2M integrates orebody characterization, blasting, and downstream processes, such as grinding and flotation, demonstrating that material fragmentation directly impacts downstream efficiency. This review studies the development and applications of fragmentation models in M2M integration and optimization, finding that their study is divided into three phases. In the first, the potential of M2M is investigated through simulation models that improve fragmentation in blasting to optimize grinding. The second focuses on the practical application of these models in mines, while the third phase integrates geometallurgical data into mine block models, enhancing production planning and selective ore extraction. The M2M integration has demonstrated significant improvements in plant performance, particularly in increasing grinding efficiency through optimized blast fragmentation. The literature also emphasizes the role of optimizing crushing and grinding conditions through models and circuit adjustments to enhance performance and reducing energy consumption. Geometallurgy plays a crucial role in plant optimization by identifying areas with better processing characteristics and adjusting operating parameters to maximize efficiency. Recent studies have shown how the implementation of integrated models can increase the profitability and sustainability of mining operations.