“…Data obtained may include medical and psychiatric diagnoses and comorbidities, clinical presentation (signs and symptoms, brain imaging findings), illness severity, medications and dosages, side effects, abuse-relevant red flags (e.g., early opioid refills), other interventions (e.g., complementary and alternative medicine therapies), genetic variables, and validated pain, psychosocial, and functional outcome measures recorded in electronic databases. Several computerized systems for comprehensive patient self-reported outcomes are already in development or in use 39,94 , including computerized adaptive testing systems such as the NIH PROMIS measures (www.nihpromis.org). Within the PBE approach, electronic medical record data can be combined with computer-based patient-reported outcomes to rapidly identify those CP patient phenotypic and genotypic characteristics that may be associated with favorable treatment outcomes, although with less certainty than with RCTs 1,2,3,37,38 .…”