Development of a new flippase-dependent mouse model for red fluorescence-based isolation of KrasG12Doncogene-expressing tumor cells
Dusan Hrckulak,
Michaela Krausova,
Jakub Onhajzer
et al.
Abstract:Proto-oncogene KRAS, GTPase (KRAS) is one of the most intensively studied oncogenes in cancer research. Although several mouse models allow for regulated expression of mutant Kras, selective isolation and analysis of transforming or tumor cells that produce the Kras oncogene remains a challenge. In our study, we present a knock-in model of oncogenic variant KrasG12D that enables the "activation" of KrasG12D expression together with production of red fluorescent protein tdTomato. Both proteins are expressed fro… Show more
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