In this research, thermal modeling has been done to investigate the effect of nanofluid on the performance of the linear parabolic collector. Therminol vapor/liquid phase fluid (VP-1) has been used as a base fluid; iron oxide nanoparticles have been used to produce mono-nanofluid; and iron oxide multi-walled carbon nanotubes nanocomposite has been used as nanoparticles to produce hybrid nanofluid. The fluid flow inside the absorber tube of the collector is assumed to be turbulent. The results show that when hybrid nanofluid and mono-nanofluid are used, the energy and exergy efficiencies of the collector are higher than those for the conditions of using the base fluid, but their amount is slightly lower with the use of hybrid nanofluid than when the working fluid is mono-nanofluid. According to the obtained results, the highest energy efficiency of the linear parabolic collector using nanofluid and mono-nanofluid is 70.2% and 70.4%, respectively, and the highest exergy efficiency is 35.7% and 35.9%, respectively. Despite this, the friction coefficient of mono-nanofluid compared to hybrid nanofluid was obtained on average about 9% higher. The results showed that the criterion for evaluating the performance of the collector (hydrodynamic thermal efficiency) when hybrid nanofluid is used is more than when mono-nanofluid is used.