Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Abstract

The estimation of trifluoperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an oxidation-reduction reaction with ceric sulfate in acidic medium the unreacted oxidant bleaches the color of complex prepared previously outside the reaction medium from reaction of 4,7diphenyl 1,10phenanthroline with ferrous ammonium sulfate to produce a red-violet colored product with a maximum absorbance of 533nm. The molar absorptivity of 0.700x10 4 L. mole -1 .cm -1 , Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine trifluoperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been suggested.