Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded solid lipid nanoparticles and doxofylline for the treatment of asthma

Pareek, Ashutosh; Kothari, Rupal; Pareek, Aaushi; Ratan, Yashumati; Kashania, Pushpa; Jain, Vivek; Jeandet, Philippe; Kumar, Parveen; Khan, Azmat Ali; Alanazi, Amer M.; Gupta, Madan Mohan

doi:10.1016/j.ejps.2023.106642

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…In addition, the release data were tted to the Korsmeyer-Peppas model, and the linearity and the release NG and NG-MOF-5@LNs were determined in Table 1. For con rming the prolonged release properties of NG from NG-MOF-5@LNs solution release t a rst-order kinetic model (R 2 = 0.9877), while NG from NG-MOF-5@LNs better t a Higuchi model (R 2 = 0.9988) as reported in [50,51]. The maximum linearity was provided with Higuchi kinetics and is consistent with previous studies [51,52].…”

Section: In Vitro Drug Release (Dr) Behaviorsupporting

confidence: 85%

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Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Elbeltagi,

Alharbi,

Aodah

et al. 2024

Preprint

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Tumors are considered dangerous due to their significant global mortality rate, with breast cancer (BC) being a major contributor to this statistic, impacting almost all tumor patients worldwide. Conventional methods for BC treatment, such as special naringin (NG) chemotherapy based on nanotechnology components, have been insufficient, and a new approach has been used to improve drug delivery (DD) to cancer. Herein, developed biocompatible nanoparticles (NPs) comprising NG-loaded zinc metal-organic framework-5 (NG-MOF-5) encapsulated with liponiosomes (LNs) to create NG-MOF-5@LNs. Various biophysical characteristics of free NG, MOF-5, and NG-MOF-5@LNs NPs were studied, including XRD, FTIR, TEM, SEM, zeta potential (ZP), hydrodynamic size, PDI, loading efficiency (LE), encapsulation efficiency (EE), drug release (DR), and drug-release kinetics. TEM images showed that NG-MOF-5@LNs NPs consisted of monodispersed spherical-like particles with average diameters of 122.5 nm (*P < 0.05). The optimized NG-MOF-5@LNs exhibited a particle size (PDI: 139.8 nm) and a ZP (+ 21 mV). The EE and LE for NG-MOF-5@LNs were 89.15% and 14.05%, respectively. Four kinetic models were examined to understand the NG release mechanism at pH 6.9, with the Higuchi model indicating excellent fit (R2 = 0.9988). The MTT cell viability assay demonstrated anti-cancer activity against MCF-7 BC cells, with inhibitory concentrations (IC50) of 231.9, 188.2, and 21.6 µg/mL (*P < 0.05) for MOF-5, NG, and NG-MOF-5@LNs, respectively, indicating an apoptosis effect on MCF-7 cells. NG-MOF-5@LNs is expected to emerge as a novel long-term-release anticancer agent. NG-MOF-5@LNs may represent a superior option for BC therapy compared to conventional NG formulations.

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Section: In Vitro Drug Release (Dr) Behaviorsupporting

confidence: 85%

“…Author et al [42], the spherical shape of drug-loaded NPs@liposomes could be attributed to which form of closed bilayer vesicles in water reduced their surface-free energy. The combination of NG-MOF-5@LNs may result in intricate interactions, which may be the cause of the lyophilized dry microparticles minor deformation [51,72,73].…”

Section: Discussionmentioning

confidence: 99%

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Elbeltagi,

Alharbi,

Aodah

et al. 2024

Preprint

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“…As the microspheres absorb water, they expand, causing their dimensions to increase. This increase in particle size may further contribute to the barrier effect within the microneedles, potentially exacerbating the hindered drug release . In a similar study, poly(ethylene glycol) diacrylate microneedles were immersed in an aqueous medium to examine their swelling behavior.…”

Section: Resultsmentioning

confidence: 99%

“…This increase in particle size may further contribute to the barrier effect within the microneedles, potentially exacerbating the hindered drug release. 53 In a similar study, poly(ethylene glycol) diacrylate microneedles were immersed in an aqueous medium to examine their swelling behavior. The size of the microspheres played a crucial role in determining the diffusion rate of the medium into the microspheres.…”

Section: Ftir Analysis Of Microneedlementioning

confidence: 99%

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Sabbagh,

Deshmukh,

Choi

et al. 2024

ACS Appl. Mater. Interfaces

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In this work, microspheres were developed by crosslinking glutaraldehyde in an aqueous gelatin solution with a surfactant and solvent. A poly(vinyl alcohol) (PVA) solution was produced and combined with catechin-loaded microspheres. Different microsphere concentrations (0%, 5%, 10%, and 15%) were applied to the PVA microneedles. The moisture content, particle size, swelling, and drug release percentage of microneedles were studied using various microsphere concentrations. Fourier transform infrared and scanning electron microscopy (SEM) investigations validated the structure of gelatin microspheres as well as their decoration in microneedles. The SEM scans revealed that spherical microspheres with a wrinkled and folded morphology were created, with no physical holes visible on the surface. The gelatin microspheres generated had a mean particle size of 20−30 μm. Ex vivo release analysis indicated that microneedles containing 10% microspheres released the most catechin, with 42.9% at 12 h and 84.4% at 24 h.

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“…Liposomes, composed of phospholipid bilayers, can encapsulate curcumin within aqueous compartments or lipid bilayers, enabling targeted delivery to specific tissues or cells while minimizing off-target effects [25]. SLNs offer advantages in terms of stability and sustained release, making them suitable candidates for encapsulating curcumin and overcoming its inherent bioavailability limitations [26]. Nanoemulsions, comprising oil-in-water or water-in-oil formulations, provide a stable platform for delivering hydrophobic compounds like curcumin, enhancing its bioavailability and therapeutic efficacy [27,28].…”

Section: Introductionmentioning

confidence: 99%

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Yakubu,

Pandey

2024

Pharmaceutics

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Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes.

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Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded solid lipid nanoparticles and doxofylline for the treatment of asthma

Cited by 10 publications

References 40 publications

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

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