Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization

Vossen, Josephina A.; Buijs, Manon; Syed, Labiq H.; Kutiyanwala, Fatima; Kutiyanwala, M.; Geschwind, Jean François H.; Vali, Mustafa

doi:10.1007/s10585-008-9195-x

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…In addition, the high local tumor control rate was confirmed by FDG-PET scans and yielded significant survival benefits for intra-arterially treated animals [68]. This rare ability of an investigative drug to achieve survival benefits in an animal tumor model was also confirmed in other animal studies, making 3-BrPA a promising candidate for clinical trials [69,70]. Additionally, another comparative trial demonstrated the encouraging potential of intra-arterial 3-BrPA infusions to effectively prevent intra-abdominal metastatic spread of VX2 tumors, known for a aggressive growth pattern [71].…”

Section: Targeting Cancer Metabolismmentioning

confidence: 89%

Targeting glucose metabolism in cancer: a new class of agents for loco-regional and systemic therapy of liver cancer and beyond?

et al. 2015

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Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. In patients with unresectable disease, loco-regional catheter-based intra-arterial therapies (IAT) can achieve selective tumor control while minimizing systemic toxicity. As molecular features of tumor growth and microenvironment are better understood, new targets arise for selective anticancer therapy. Particularly, antiglycolytic drugs that exploit the hyperglycolytic cancer cell metabolism – also known as the ‘Warburg effect’ – have emerged as promising therapeutic options. Thus, future developments will combine the selective character of loco-regional drug delivery platforms with highly specific molecular targeted antiglycolytic agents. This review will exemplify literature on antiglycolytic approaches and particularly focus on intra-arterial delivery methods.

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Section: Targeting Cancer Metabolismmentioning

confidence: 89%

Targeting glucose metabolism in cancer: a new class of agents for loco-regional and systemic therapy of liver cancer and beyond?

et al. 2015

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“…In the last 10 years, the medical science has been noticing even more the potential of the white rabbit (Oryctolagus cuniculus) of the New Zealand lineage 1 as an experimental animal model for the research in video-surgery, general surgery, orthopedics, gynecology, vascular, craniofacial and urologic [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . However, there are few information with a good scientific evidence, regarding the perioperative care [2][3][4][5][6][7][8][9][10][11][12][13][14][15]17 .…”

Section: Introductionmentioning

confidence: 99%

“…However, there are few information with a good scientific evidence, regarding the perioperative care [2][3][4][5][6][7][8][9][10][11][12][13][14][15]17 .…”

Section: Introductionmentioning

confidence: 99%

“…For abdominal surgical procedures through laparotomy, it was proposed in several studies different anesthetic protocols for many isolated or combined routes: inhalation, endovenous, epidural and intramuscular, depending on the effects related to the anesthetic used and the physiological and behavioral parameters related to the rabbits 2,[4][5][6][7][8][9][10][11][12][13][14][15]17,[22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

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Perioperative care in an animal model for training in abdominal surgery: is it necessary a preoperative fasting?

2011

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PURPOSE:Demonstrate that the rabbit may be used in the training of surgery, in addition to present its perioperative care. METHODS:Thirty two animals, with age and weight, respectively, from 3 to 5.5 months old and 3000 to 4200 grams, were undergone different periods of pre-operative fasting, exclusive intramuscular anesthesia (ketamine+xylazine), laparotomy with total gastrectomy and total splenectomy. It was dosed the pre-operative (initial) and post-surgical (end) serum blood glucose, in addition to quantify the gastric content after the resection of the part. RESULTS:The anesthetical-surgical procedure presented a mortality rate of 3.125% (1:32) and a morbidity rate of 6.25% (2:32). It was evidenced an initial mean blood glucose = 199.4 mg/dl and the end = 326.1 mg/dl. In spite of extended fasting (minimum of 2 hours for the absolute fasting and maximum of 8.5 hours for liquids, and 20.5 hours for solids) all animals presented at the end of the surgical procedure any gastric content and a blood glucose increase. Those with fasting for liquids and solids when compared to the quantity of solid gastric content, presented a moderate negative degree of correlation. CONCLUSION:The rabbit is a good model to be used in training of surgery, with a low morbi-mortality, able to be anesthetized intramuscularly, with no need of pre-operative fasting and does not present hypoglycemia even with the extended fasting period. Keywords: Animal Experimentation. Surgery. Fasting. Blood Glucose. Rabbits. RESUMO OBJETIVO:Demonstrar que o coelho pode ser utilizado no treinamento em cirurgia, além de apresentar seus cuidados perioperatórios. MÉTODOS:Trinta e dois animais, com idade e peso respectivamente, entre 3 a 5,5 meses e 3000 a 4200 gramas, foram submetidos a variados tempos de jejum pré-operatório, anestesia intramuscular exclusiva (quetamina+xilasina), laparotomia com gastrectomia e esplenectomia totais. Dosou-se a glicemia sérica pré-operatória (inicial) e pós-cirúrgica (final), além de quantificado o conteúdo gástrico pós-gastrectomia. RESULTADOS: O procedimento anestésico-cirúrgico apresentou taxa de mortalidade de 3,125 % (1:32) e morbidade de 6,25 % (2:32). Evidenciou-se glicemia média inicial = 199,4 mg/dl e final = 326,1 mg/dl. Apesar de jejuns prolongados (mínimo de 2 horas para jejum absoluto e máximo de 8,5 horas para líquidos, e 20,5 horas para sólidos) todos os animais apresentaram no final do procedimento cirúrgico algum conteúdo gástrico e aumento da glicemia. Aqueles com jejum para líquidos e sólidos quando comparados com a quantidade de conteúdo gástrico sólido e total apresentaram grau moderadamente negativo de correlação linear. CONCLUSÃO:O coelho é um bom modelo para ser utilizado em treinamento de cirurgia, com baixa morbimortalidade, passível de ser anestesiado por via intramuscular, sem necessidade de jejum pré-operatório e ausência de hipoglicemia.

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“…As a glycolytic inhibitor, "3BP is a fast acting, promising, powerful, specific and effective anti-cancer agent", said by Pedersen 3 . Also 3BP has been identified to inhibit tumor cells proliferation as a proposed widely used anti-cancer agent 4 , such as in breast cancer cells 5,6 , liver cancer cells 7,8 , lymphoma cells 9 , lung cancer cells 10 , pancreatic cancer cells 11,12 , gastric cancer 2,13 , colorectal cancer cells 14 . Those significant anti-tumor effects of 3BP has made it getting more and more attention 15,16 .…”

mentioning

confidence: 99%

Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice

Pan¹,

Sun²,

Jin³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To investigate the hepatotoxicity and nephrotoxicity of 3-Bromopyruvate (3BP) in mice. hours later, the blood were used for the determination of hepatic damage serum biomarkers. Livers were stored in 4 % formalin solution for the later detection. METHODS: RESULTS:3BP at the dose of 8mg/kg had a good effect on inhibiting tumor growth in nude mice and did not damage liver and kidney tissues. Kunming mice experiment showed 3BP at the dose of 16mg/kg did damage to liver tissues. CONCLUSION:3-Bromopyruvate at the dose of suppressing tumor growth did not exhibit hepatotoxicity and nephrotoxicity in nude mice, and the effect on liver was confirmed in Kunming mice.

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Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization

Cited by 18 publications

References 26 publications

Targeting glucose metabolism in cancer: a new class of agents for loco-regional and systemic therapy of liver cancer and beyond?

Targeting glucose metabolism in cancer: a new class of agents for loco-regional and systemic therapy of liver cancer and beyond?

Perioperative care in an animal model for training in abdominal surgery: is it necessary a preoperative fasting?

Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice

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