Development of a new poly-ε-caprolactone with low melting point for creating a thermoset mask used in radiation therapy

Aoyama, Tomoo; Uto, Koichiro; Shimizu, Hidetoshi; Ebara, Mitsuhiro; Kitagawa, Tomoki; Tachibana, Hideki; Suzuki, Kôjiro; Kodaira, Takeshi

doi:10.1038/s41598-021-00005-2

Cited by 5 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The melting point of PCL is typically around 55 to 60 • C [52][53][54]. Regardless of the inclusion of ceramic filler, the melting temperature remains consistent between 55 and 60 • C for all scaffolds.…”

Section: Thermal Propertiesmentioning

confidence: 92%

3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

Emadi,

Baghani,

Masoudi Rad

et al. 2024

Polymers

View full text Add to dashboard Cite

There is an essential clinical need to develop rapid process scaffolds to repair bone defects. The current research presented the development of calcium zirconium silicate/polycaprolactone for bone tissue engineering utilising melt extrusion-based 3D printing. Calcium zirconium silicate (CZS) nanoparticles were added to polycaprolactone (PCL) porous scaffolds to enhance their biological and mechanical properties, while the resulting properties were studied extensively. No significant difference was found in the melting point of the samples, while the crystallisation temperature points of the samples containing bioceramic increased from 36.1 to 40.2 °C. Thermal degradation commenced around 350 °C for all materials. According to our results, increasing the CZS content from 0 to 40 wt.% (PC40) in porous scaffolds (porosity about 55–62%) improved the compressive strength from 2.8 to 10.9 MPa. Furthermore, apatite formation ability in SBF solution increased significantly by enhancing the CZS percentage. According to MTT test results, the viability of MG63 cells improved remarkably (~29%) in PC40 compared to pure PCL. These findings suggest that a 3D-printed PCL/CZS composite scaffold can be fabricated successfully and shows great potential as an implantable material for bone tissue engineering applications.

show abstract

Section: Thermal Propertiesmentioning

confidence: 92%

3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

Emadi,

Baghani,

Masoudi Rad

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…Their shape does not change until the day of the operation, thus there is no requirement for the markers to be placed between the time of preoperative imaging and the day of the procedure. A common marker based on this concept is the Thermoset facial mask used for immobilizing the patient’s head-and-neck for radiotherapy [ 46 ]. More on this subject will be discussed in the invasiveness section.…”

Section: Registration Methodsmentioning

confidence: 99%

Image-to-Patient Registration in Computer-Assisted Surgery of Head and Neck: State-of-the-Art, Perspectives, and Challenges

Taleb,

Guigou,

Leclerc

et al. 2023

JCM

View full text Add to dashboard Cite

Today, image-guided systems play a significant role in improving the outcome of diagnostic and therapeutic interventions. They provide crucial anatomical information during the procedure to decrease the size and the extent of the approach, to reduce intraoperative complications, and to increase accuracy, repeatability, and safety. Image-to-patient registration is the first step in image-guided procedures. It establishes a correspondence between the patient’s preoperative imaging and the intraoperative data. When it comes to the head-and-neck region, the presence of many sensitive structures such as the central nervous system or the neurosensory organs requires a millimetric precision. This review allows evaluating the characteristics and the performances of different registration methods in the head-and-neck region used in the operation room from the perspectives of accuracy, invasiveness, and processing times. Our work led to the conclusion that invasive marker-based methods are still considered as the gold standard of image-to-patient registration. The surface-based methods are recommended for faster procedures and applied on the surface tissues especially around the eyes. In the near future, computer vision technology is expected to enhance these systems by reducing human errors and cognitive load in the operating room.

show abstract

“…PCL is produced by polymerisation of ε-caprolactone via cationic, anionic, or radical polymerisation methods [111,112]. It is a biodegradable [113,114], semicrystalline, aliphatic thermoplastic with a glass transition temperature (Tg) of −60 • C [115], and with a typical melting point of ~60 • C [116][117][118], tuneable down to 46 • C [119]. The availability of different molecular weight PCL's results in tailorable degradation kinetics over months or years, depending on the tissue engineering application [117].…”

Section: Polycaprolactonementioning

confidence: 99%

Laser Sintering Approaches for Bone Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

The adoption of additive manufacturing (AM) techniques into the medical space has revolutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue such as bone, powder bed fusion (PBF) techniques have significant potential, as they are capable of fabricating materials that can match the mechanical requirements necessary to maintain bone functionality and support regeneration. This review focuses on the PBF techniques that utilize laser sintering for creating scaffolds for bone tissue engineering (BTE) applications. Optimal scaffold requirements are explained, ranging from material biocompatibility and bioactivity, to generating specific architectures to recapitulate the porosity, interconnectivity, and mechanical properties of native human bone. The main objective of the review is to outline the most common materials processed using PBF in the context of BTE; initially outlining the most common polymers, including polyamide, polycaprolactone, polyethylene, and polyetheretherketone. Subsequent sections investigate the use of metals and ceramics in similar systems for BTE applications. The last section explores how composite materials can be used. Within each material section, the benefits and shortcomings are outlined, including their mechanical and biological performance, as well as associated printing parameters. The framework provided can be applied to the development of new, novel materials or laser-based approaches to ultimately generate bone tissue analogues or for guiding bone regeneration.

show abstract

Development of a new poly-ε-caprolactone with low melting point for creating a thermoset mask used in radiation therapy

Cited by 5 publications

References 32 publications

3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

Image-to-Patient Registration in Computer-Assisted Surgery of Head and Neck: State-of-the-Art, Perspectives, and Challenges

Laser Sintering Approaches for Bone Tissue Engineering

Contact Info

Product

Resources

About