Development of a Non–Heart-Beating Donor Program and Results After the First Year

Meneses, José Carlos; Gámez, Pablo; Mariscal, A.; Marrón, Carmen; Díaz-Hellín, V.; Cortes, Marcelino; Pablo, Alicia de; López, E.; Pérez, Vera Z.; González, O.; Juarros, Lourdes; Martinez, I.; F, Hermoso; Ávila, Ramiro; Zuluaga, Mauricio Zuluaga; Nicolás, J.L. Martín de

doi:10.1016/j.transproceed.2012.07.092

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Importantly, no recipients experienced grade-3 PGD (47). This result is in contrast to grade-3 PGD rates (up to 38%) reported in previous studies that evaluated uDCD LTx without to be combined with EVLP (48)(49)(50).…”

Section: Clinical Evlp Using the Toronto Methods For Dcd Donor Lungscontrasting

confidence: 96%

Ex vivo lung perfusion

Reeb

Cypel

2016

Clinical Transplantation

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Lung transplantation is an established life-saving therapy for patients with end-stage lung disease. Unfortunately, greater success in lung transplantation is hindered by a shortage of lung donors and the relatively poor early-, mid-, and long-term outcomes associated with severe primary graft dysfunction. Ex vivo lung perfusion has emerged as a modern preservation technique that allows for a more accurate lung assessment and improvement in lung quality. This review outlines the: (i) rationale behind the method; (ii) techniques and protocols; (iii) Toronto ex vivo lung perfusion method; (iv) devices available; and (v) clinical experience worldwide. We also highlight the potential of ex vivo lung perfusion in leading a new era of lung preservation.

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Section: Clinical Evlp Using the Toronto Methods For Dcd Donor Lungscontrasting

confidence: 96%

Ex vivo lung perfusion

Reeb

Cypel

2016

Clinical Transplantation

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“…In uncontrolled DCD, an unsuccessful resuscitation with declaration of death is followed by insertion of chest tubes with in situ cooling of the lungs and a preservation solution and intravenous heparin, followed by consent for donation and subsequent recovery of organs. 12,28 Teams in Spain have demonstrated the feasibility of this approach, 12,[29][30][31] and efforts are underway to demonstrate feasibility in other locales. 32 Several trials are underway which aim to optimize donor lung preservation in the preretrieval phase.…”

Section: Donation After Circulatory Deathmentioning

confidence: 99%

The Future of Lung Transplantation

Young

Dilling

2019

Chest

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The field of lung transplant has made significant advances over the last several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overcome several stumbling blocks, including donor shortage, proper selection of candidates, primary graft dysfunction, and chronic lung allograft dysfunction. The advances and developments surrounding these factors will have a significant impact on shaping the field within the coming years. In this review, we look at the current climate (ripe for expanding the donor pool), new technology (ex vivo lung perfusion and bioengineered lungs), cutting-edge innovation (novel biomarkers and new ways to treat infected donors), and evidence-based medicine to discuss current trends and predict future developments for what we hope is a bright future for the field of lung transplantation.

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“…L'ECMO VA femorofemorale è utilizzata per la preservazione regionale normotermica degli organi addominali dei DNBC non controllati. In questo contesto, i polmoni sono esclusi dalla circolazione mediante un palloncino posizionato in aorta discendente e sono mantenuti in ipotermia attraverso una perfusione pleurica di Perfadex ® a 4 • C. Si parla di conservazione bi-termica [66,67] . Il primo trapianto di polmone che utilizzava un innesto di DCNB è datato 2001 [68] .…”

Section: Prelievo D'organo In Donatore a Cuore Non Battenteunclassified