Development of a novel aqueous hydroxyapatite suspension for stereolithography applied to bone tissue engineering

Wang, Zhen; Huang, Chuanzhen; Wang, Jun; Zou, Bin

doi:10.1016/j.ceramint.2018.11.063

Cited by 74 publications

(48 citation statements)

References 23 publications

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“…Ronca et al [25] successfully prepared poly(d,l-lactide)/nanosized HA biocomposite structures by the stereolithography method. Skoog et al [26] and Wang et al [27] also obtained HA bioceramics for bone tissue engineering. Lasgorceix et al [28] developed a novel microstereolithography technique to prepare macro-micro-porous silicon substituted HA bioceramic.…”

Section: Introduction mentioning

confidence: 99%

Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility

et al. 2020

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Hydroxyapatite (HA) bioceramic scaffolds were fabricated by using digital light processing (DLP) based additive manufacturing. Key issues on the HA bioceramic scaffolds, including dispersion, DLP fabrication, sintering, mechanical properties, and biocompatibility were discussed in detail. Firstly, the effects of dispersant dosage, solid loading, and sintering temperature were studied. The optimal dispersant dosage, solid loading, and sintering temperature were 2 wt%, 50 vol%, and 1250 ℃, respectively. Then, the mechanical properties and biocompatibility of the HA bioceramic scaffolds were investigated. The DLP-prepared porous HA bioceramic scaffold was found to exhibit excellent mechanical properties and degradation behavior. From this study, DLP technique shows good potential for manufacturing HA bioceramic scaffolds.

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Section: Introduction mentioning

confidence: 99%

Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility

et al. 2020

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“…The general opinion in the literature is that the smaller particle size enhances the viscosity of the suspension . Wang et al reported that the reduced particle size in the HA suspension caused to enhance the viscosity could be due to the increasing interaction forces between the smaller particles. Ryabenkova also observed that the viscosity of the injectable nano‐HA paste that prepared from the smaller and more rounded particles was higher than that of the larger particles.…”

Section: Resultsmentioning

confidence: 99%

Role of strontium substitution in spray drying of hydroxyapatite: A comparative study on physical properties

Baştan

Erdoğan

Üstel

2019

Int J Applied Ceramic Tech

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Spray drying (SD) has the ability to tailor granule size and morphology, thus, it is used for producing hydroxyapatite (HA) granules. Recently, Sr functionalized HA (SrHA) has been recommended owing to its improved biological properties. The aim of this article was to produce SrHA granules with the combination of nanoparticle synthesis and spray-drying. The effects of substitution on the physical properties of SrHA nanoparticles and spray-dried granules were investigated. TEM analyzes revealed that Sr substitution reduced the mean size of HA nanoparticles from 4.59 nm to 2.31 nm. Besides, Sr substitution increased the viscosity of the prepared slurry for spray drying, which may be attributed to the smaller nanoparticle sizes. The reduced nanoparticle size caused to the agglomeration of the SrHA more than the pure HA nanoparticles. Moreover the 16 mol % Sr substituted HA (16SrHA) slurry were quickly hardened, which hampered the feeding of the slurry to the SD system; eventually the atomizer was blocked. The increase in the viscosity increased the mean granule size of HA from 41.53 µm to 49.18 µm. HA and 8SrHA granules presented HA phase dominantly after the heat treatment at 1000°C, while, 16SrHA decomposed to TCP according to RAMAN and XRD investigations. K E Y W O R D Shydroxyapatite, RAMAN spectroscopy, spray drying, transmission electron microscopy 1156 | BASTAN eT Al.

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“…In this technique, a photopolymer will be cured and harden according to the 3D designed model using a light source, where the viscosity of raw materials can affect the final structure. 45,52 Limitations in the number of suitable materials, restriction in geometric fidelity, and dependency of accuracy to laser beam diameter are the observed challenge in this method. 53 FDM technology (Figure 1(c)) is a low cost, simple, high speed, and commonly used method to fabricate thermoplastic-based scaffolds.…”

Section: Bioprinting As An Innovative Technology For Bone Regenerationmentioning

confidence: 99%

“…SLA technique (Figure 1(b)) is another subset of 3D printing technology techniques to create tissue engineering scaffolds due to the applicability of biologically relevant photopolymers. In this technique, a photopolymer will be cured and harden according to the 3D designed model using a light source, where the viscosity of raw materials can affect the final structure 45,52 . Limitations in the number of suitable materials, restriction in geometric fidelity, and dependency of accuracy to laser beam diameter are the observed challenge in this method 53 .…”

Section: Bioprinting As An Innovative Technology For Bone Regenerationmentioning

confidence: 99%

Bioprinting a cell‐laden matrix for bone regeneration: A focused review

Ghorbani

Zhong

et al. 2020

J of Applied Polymer Sci

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Although many efforts have been made to regenerate the bone lesions, existing challenges can be mitigated through the development of tissue engineering scaffolds. However, the weak control on the microstructure of constructs, limitation in preparation of patient-specific and multilayered scaffolds, restriction in the fabrication of cell-laden matrixes, and challenges in preserving the drug/growth factors' efficacy in conventional methods have led to the development of bioprinting technology for regeneration of bone defects. So in this review, conventional 3D printers are classified, then the priority of the different types of bioprinting technologies for the preparation of the cell/growth factor-laden matrixes are focused. Besides, the bio-ink compositions, including polymeric/hybrid hydrogels and cell-based bio-inks are classified according to fundamental and recent studies. Herein, different effective parameters, such as viscosity, rheological properties, cross-linking methods, biodegradation biocompatibility, are considered. Finally, different types of cells and growth factors that can encapsulate in the bio-inks to promote bone repair are discussed, and both in vitro and in vivo achievement are considered. This review provides current and future perspectives of cell-laden bioprinting technologies. The restrictions and challenges are identified, and proper strategies for the development of cell-laden matrixes and high-performance printable bio-inks are proposed.

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Development of a novel aqueous hydroxyapatite suspension for stereolithography applied to bone tissue engineering

Cited by 74 publications

References 23 publications

Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility

Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility

Role of strontium substitution in spray drying of hydroxyapatite: A comparative study on physical properties

Bioprinting a cell‐laden matrix for bone regeneration: A focused review

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