Development of a novel carrier optimized for cell sheet transplantation

Poly-l/dl-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells

“…Several analogs of PLA have been used in different biomedical applications as well as in advanced therapy drugs in tissue engineering. In the field of ophthalmology, some members of the PLA family (pure or combined with other materials) are being used in preclinical studies [37]. However, it is known that PLA alone is not adequate for the adhesion of some cell types [38,39].…”

“…Polylactic acid has been used in several biomedical applications, such as absorbable sutures, a transport medium for drug delivery, and tissue engineering [29,31]. Currently, the use of polylactic acid has expanded significantly in the field of bone regeneration [32][33][34] and combined with glycolic acid (polylactic-glycolic acid) in conjunctival and corneal reconstruction [35][36][37]. However, it has been demonstrated that cell adhesion to polylactic acid films is poor, and that it is necessary to functionalize the surface of this type of polymer to improve cell attachment [38,39].…”

High intensity focused ultrasound cyclocoagulation in dogs with primary glaucoma: a preliminary study

“…Structural abnormality of the conventional outflow pathway comprising the pectinate ligament, the uveal and corneoscleral trabecular meshworks and the ciliary cleft (Read et al, 1998;Wood et al, 1998;Bjerkas et al, 2002;Kato et al, 2006;Strom et al, 2011;Plummer et al, 2013;Fricker et al, 2016;Bedford, 2017), or an abnormal biochemical metabolism of the trabecular meshworks (Hassel et al, 2007;Weinstein et al, 2007;Mackay et al, 2008aMackay et al, , 2008b), may be responsible for PG. Many surgical techniques have been described to manage PG, acting either on the production (De Roetth, 1965;Brightman et al, 1982;Hardman and Stanley, 2001;Lutz and Sapienza, 2009a;Azoulay et al, 2011;Harrington et al, 2013) or the egress of aqueous humor (Cullen et al, 1998;Cullen, 2004), or both at the same time (Sapienza and van der Woerdt, 2005;Lutz and Sapienza, 2009b;Amagai et al, 2014). Cyclocryothermy (De Roetth, 1965;Brightman et al, 1982), transscleral cyclophotocoagulations (TSCP) (Hardman and Stanley, 2001;Sapienza and van der Woerdt, 2005;Amagai et al, 2014) and endocyclophotocoagulation (ECP) (Lutz and Sapienza, 2009a,b;Azoulay et al, 2011;Harrington et al, 2013) http://www.openveterinaryjournal.com P.F.…”

“…Many surgical techniques have been described to manage PG, acting either on the production (De Roetth, 1965;Brightman et al, 1982;Hardman and Stanley, 2001;Lutz and Sapienza, 2009a;Azoulay et al, 2011;Harrington et al, 2013) or the egress of aqueous humor (Cullen et al, 1998;Cullen, 2004), or both at the same time (Sapienza and van der Woerdt, 2005;Lutz and Sapienza, 2009b;Amagai et al, 2014). Cyclocryothermy (De Roetth, 1965;Brightman et al, 1982), transscleral cyclophotocoagulations (TSCP) (Hardman and Stanley, 2001;Sapienza and van der Woerdt, 2005;Amagai et al, 2014) and endocyclophotocoagulation (ECP) (Lutz and Sapienza, 2009a,b;Azoulay et al, 2011;Harrington et al, 2013) http://www.openveterinaryjournal.com P.F. Isard et al Open Veterinary Journal, (2018), Vol.…”

“…This technique has become progressively obsolete and was mainly used to reduce IOP in blind patients with persistent pain. Transscleral diode or Nd: YAG laser cyclophotocoagulations have been studied in veterinary medicine (Hardman and Stanley, 2001;Sapienza and van der Woerdt, 2005;Amagai et al, 2014). They aim to destroy the ciliary processes with focused laser energy.…”