Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis

Dai, Zhaoxing; Yu, Xiaoling; Hong, Jiaxu; Liu, Xi; Sun, Jianguo; Sun, Xinghuai

doi:10.1016/j.msec.2016.04.077

Cited by 23 publications

(26 citation statements)

References 52 publications

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“…1a) were prepared as previously described. 20 The grooved GDDs with a radial groove pattern on their surfaces (Fig. 1b) were prepared in a special stainless steel mold using a similar method.…”

Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

“…1b) were prepared in a special stainless steel mold using a similar method. 20 The mold contained an elliptical depression and some radial ridges with a major axis of 7.68 mm and a minor axis of 6.24 mm. A medical-grade silicone tube was inserted into the hole of the GDD body and some liquid silicone (as used to prepare the GDDs) was used to stick the silicone tube to the GDD body in a solidifying process.…”

Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

“…The coating of CsA-PLGA was applied to the GDD surface as described in our prior report. 20 Optical microscopy and field emission scanning electron microscopy (FESEM, Ultra 55; Zeiss Germany, Oberkochen, Germany) were performed to observe the surface characteristics of the GDD before and after CsA-PLGA coating.…”

Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

“…19 In our recently published paper, we developed a novel GDD coated with CsA and poly (lactic-co-glycolic acid) polymer (CsA-PLGA) for continuous drug delivery in order to prevent scar formation after glaucoma surgery. 20 Moreover, we thought that modifying the GDD-with surface grooves, for example-might enhance the drainage function and antiscar effects of the GDD. In our recent study, we designed a GDD with a radial groove pattern on its surface and prepared and tested the modified GDDs.…”

mentioning

confidence: 99%

“…In our recent study, we designed a GDD with a radial groove pattern on its surface and prepared and tested the modified GDDs. 20 A composite CsA-PLGA coating can also be applied to the grooved GDD surface. The composite coating released CsA at a safe and an effective concentration for ‡12 weeks.…”

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Grooved Glaucoma Drainage Devices That Continuously Deliver Cyclosporine A Decrease Postsurgical Scar Formation in Rabbit Eyes

Dai

Sun

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Dai Z, Yu X, Sun J, Sun X. Grooved glaucoma drainage devices that continuously deliver cyclosporine A decrease postsurgical scar formation in rabbit eyes. Invest Ophthalmol Vis Sci. 2017;58:169258: -170158: . DOI: 10.1167 PURPOSE. To study the functional outcomes of filtration surgery by implanting improved glaucoma drainage devices (GDDs) comprising surface grooves and a composite coating of cyclosporine A (CsA) and PLGA in experimental rabbit eyes.METHODS. Improved GDDs were designed and prepared by modifying normal GDD with surface grooves and a CsA-PLGA composite coating. Normal GDDs, grooved GDDs (G-GDDs), and GGDDs with a CsA-PLGA composite coating (CsA@G-GDD) were implanted into 18 rabbit eyes (six eyes per group). The intraocular pressure (IOP), bleb survival time, bleb morphology, and anterior chamber reactions were assessed for up to 12 weeks after GDD implantation. The IOPs were compared statistically among the three groups. Bleb morphology was quantified using the Indiana Bleb Appearance Grading Scale. Anterior chamber radiography was performed to check whether the filtrating pathway was blocked, and determine the drainage time and diffusion area of the contrast agent. Hematoxylin and eosin staining and immunohistochemistry were conducted to assess how the GDDs slowed or prevented scar formation.RESULTS. The improved GDDs were successfully prepared and implanted in 18 rabbit eyes without severe surgical complications. Bleb survival time was significantly longer and IOP was significantly lower in the G-GDD and CsA@G-GDD groups compared with the GDD group (all, P < 0.001). Blebs were significantly higher in the CsA@G-GDD group than in the GDD and G-GDD groups (P ¼ 0.003). Anterior chamber radiography revealed more unobstructed filtration channels in the CsA@G-GDD group than in the GDD group (P ¼ 0.032). Postsurgical scar formation was less extensive in the G-GDD and CsA@G-GDD groups than in the GDD group.CONCLUSIONS. Compared with the normal GDDs, G-GDDs with a CsA-PLGA coating inhibited postsurgical scar formation and improved the surgical success rate, and might represent an alternative to existing glaucoma filtration devices.Keywords: glaucoma drainage devices, cyclosporine A, groove, filtration surgery, scar formation G laucoma is characterized by elevated intraocular pressure (IOP) and frequently causes optic neuropathy. If left untreated, it causes chronic progressive degeneration of retinal ganglion cells and visual field loss.1,2 The treatment of glaucoma typically begins with topical medications and then filtering surgeries. 3 Glaucoma filtration surgery seeks to achieve incomplete healing to allow the aqueous humor to escape the eye, unlike other surgical procedures in which complete wound healing is desired. 4 Unfortunately, IOP often increases after surgery owing to scar formation in the wound field. The success rate of trabeculectomy was reported to be 64.7% over 5 years in eyes with open-angle glaucoma. 5 In complicated cases, implantation of a glaucoma drainage device (GDD) is...

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Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

Section: Preparation and Characterization Of The Gddsmentioning

confidence: 99%

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confidence: 99%

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