2016
DOI: 10.1016/j.colsurfb.2016.08.010
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Development of a novel l-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability

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Cited by 38 publications
(11 citation statements)
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“…Owing to its oily properties, PLAG is practically insoluble in water, resulting in low oral bioavailability [11]. Generally, solid formulations, containing a lipophilic drug, and liquid SMEDDS have poor flow ability [23].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Owing to its oily properties, PLAG is practically insoluble in water, resulting in low oral bioavailability [11]. Generally, solid formulations, containing a lipophilic drug, and liquid SMEDDS have poor flow ability [23].…”
Section: Resultsmentioning
confidence: 99%
“…Various solubility and bioavailability enhancement approaches, such as solid dispersion [5], micronization [6], permeation enhancers [7], use of surface-active agents [8], pH modification [9] and self-emulsifying drug delivery systems [10], have been applied to poorly water-soluble drugs. Hence, due consideration has been given to self-emulsifying drug delivery systems that are easily manufactured for oily drugs [11]. The self-emulsifying drug delivery systems, drug-loaded blends of oils, surfactants, and co-surfactants, can be used to increase dissolution and absorption due to the spontaneous formation of a submicron droplet size.…”
Section: Introductionmentioning
confidence: 99%
“…Vitamin E TPGS has been approved with Generally Recognized As Safe (GRAS) status when used as an oral dietary supplement of vitamin E 10. In drug delivery systems, vitamin E TPGS has been used as an oral absorption enhancer of lipophilic drugs, such as paclitaxel,11,12 cyclosporine,13 l-sulpiride14and amprenavir. 15 …”
Section: Introductionmentioning
confidence: 99%
“…There were various solubility enhancing systems applied, such as supersaturation, supercritical antisolvent process, self‐microemulsifying drug delivery system, and micelles, to improve aqueous solubility and dissolution of poorly water‐soluble sirolimus. A prevalent technique for preparing dry powder of solid dispersions from liquid phase is spray drying because it is a one‐step process that gives sufficient output and is easy to scale up . Solvent‐evaporated solid dispersion methods have proven to be the most efficient way to improve the aqueous solubility and dissolution of poorly water‐soluble drugs .…”
Section: Introductionmentioning
confidence: 99%