Development of a novel liposomal nanoparticle formulation of cisplatin to breast cancer therapy

Ghafari, Mehrnaz; Haghiralsadat, Fateme; Falahati-Pour, Soudeh Khanamani; Reza, Javad Zavar

doi:10.1002/jcb.29651

Cited by 27 publications

(8 citation statements)

References 17 publications

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“…Furthermore, the half maximal inhibitory concentration (IC 50 ) of the CDDP-loaded (core/shell)/shell NPs (4.57 ± 0.33 μg/mL) was ≈ 1.6-fold less than that of this platinum-based anticancer drug (7.48 ± 0.37 μg/mL) ( p < 0.05). This greater in-vitro cytotoxic activity agrees with preceding research in which CDDP loading to nanoparticulate systems is postulated to enable cellular uptake in malignant tissues [ 142 , 143 ].…”

Section: Resultssupporting

confidence: 90%

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

2021

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A (core/shell)/shell nanostructure (production performance ≈ 50%, mean diameter ≈ 330 nm) was built using maghemite, PLGA, and chitosan. An extensive characterization proved the complete inclusion of the maghemite nuclei into the PLGA matrix (by nanoprecipitation solvent evaporation) and the disposition of the chitosan shell onto the nanocomposite (by coacervation). Short-term stability and the adequate magnetism of the nanocomposites were demonstrated by size and electrokinetic determinations, and by defining the first magnetization curve and the responsiveness of the colloid to a permanent magnet, respectively. Safety of the nanoparticles was postulated when considering the results from blood compatibility studies, and toxicity assays against human colonic CCD-18 fibroblasts and colon carcinoma T-84 cells. Cisplatin incorporation to the PLGA matrix generated appropriate loading values (≈15%), and a dual pH- and heat (hyperthermia)-responsive drug release behaviour (≈4.7-fold faster release at pH 5.0 and 45 °C compared to pH 7.4 and 37 °C). The half maximal inhibitory concentration of the cisplatin-loaded nanoparticles against human lung adenocarcinoma A-549 cells was ≈1.6-fold less than that of the free chemotherapeutic. Such a biocompatible and tri-stimuli responsive (maghemite/PLGA)/chitosan nanostructure may found a promising use for the effective treatment of lung cancer.

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Section: Resultssupporting

confidence: 90%

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

2021

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“…15,16 Nanotechnology can provide emergence of fundamental changes in how to deal with the approaches to potentially treat cancer. 17,18 On another side, the overuse of antibiotics to kill the bacteria has made them resistant to antibiotics and spread infectious diseases. 19 Therefore, it is essential to look for new antibacterial substances (new generation of antibacterial drugs) to prevent the growth of bacteria.…”

Section: Introductionmentioning

confidence: 99%

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Arsalan

Kashi

Hasan

et al. 2020

IJN

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The interaction of NPs with biological systems may reveal useful details about their pharmacodynamic, anticancer and antibacterial effects. Methods: Herein, the interaction of as-synthesized Co 3 O 4 NPs with HSA was explored by different kinds of fluorescence and CD spectroscopic methods, as well as molecular docking studies. Also, the anticancer effect of Co 3 O 4 NPs against leukemia K562 cells was investigated by MTT, LDH, caspase, real-time PCR, ROS, cell cycle, and apoptosis assays. Afterwards, the antibacterial effects of Co 3 O 4 NPs against three pathogenic bacteria were disclosed by antibacterial assays. Results: Different characterization methods such as TEM, DLS, zeta potential and XRD studies proved that fabricated Co 3 O 4 NPs by sol-gel method have a diameter of around 50 nm, hydrodynamic radius of 177 nm with a charge distribution of −33.04 mV and a welldefined crystalline phase. Intrinsic, extrinsic, and synchronous fluorescence as well as CD studies, respectively, showed that the HSA undergoes some fluorescence quenching, minor conformational changes, microenvironmental changes as well as no structural changes in the secondary structure, after interaction with Co 3 O 4 NPs. Molecular docking results also verified that the spherical clusters with a dimension of 1.5 nm exhibit the most binding energy with HSA molecules. Anticancer assays demonstrated that Co 3 O 4 NPs can selectively lead to the reduction of K562 cell viability through the cell membrane damage, activation of caspase-9,-8 and-3, elevation of Bax/Bcl-2 mRNA ratio, ROS production, cell cycle arrest, and apoptosis. Finally, antibacterial assays disclosed that Co 3 O 4 NPs can stimulate a promising antibacterial effect against pathogenic bacteria. Conclusion: In general, these observations can provide useful information for the early stages of nanomaterial applications in therapeutic platforms.

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“…Nano-LIP are the most commonly used nano-carrier to deliver drugs to human tissues in clinical applications and have been approved by the US Food and Drug Administration. 34 OMT has been reported to ameliorate agomelatine-induced hepatocyte toxicity 35 and is safe for the treatment of hepatitis B cirrhosis. 36 Furthermore, OMT improved lesions in patients with severe psoriasis without obvious toxicity.…”

Section: Discussionmentioning

confidence: 99%

<p>Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments</p>

Wang

Ding

Zhang

et al. 2020

DDDT

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Intervertebral disc degeneration (IVDD) is the main cause of modern low back pain, leading to high societal economic costs. To find an effective medical treatment for this disease, oxymatrine liposomes (OMT-LIP) were prepared with the pH-gradient method. Materials and Methods: Nucleus pulposus (NP) cells from Sprague-Dawley rats were used for the cell experiments. Kunming mice were used for in vivo imaging. LIP were employed to deliver OMT, and the particle size, ζ-potential, morphology, in vitro stability and in vitro release characteristics were evaluated. The OMT-LIP targeting effect was measured by in vivo imaging. Cell Counting Kit-8 assays were used to detect the cytotoxicity of OMT and OMT-LIP on NP cells. Therapeutic efficacy was measured by Western blot, real-time quantitative polymerase chain reaction, and apoptosis assays. Radiologic analysis was performed to evaluate the therapeutic effects in vivo. Results: Orthogonal test results revealed that the mass ratio of egg yolk phosphatidylcholine to cholesterol was the key factor to effectively trap OMT in LIP. Optimal OMT-LIP showed multivesicular structure with entrapment efficiency of 73.4 ± 4.1%, particle size of 178.1 ± 2.9 nm, and ζ-potential of -13.30 ± 2.34 mV. OMT-LIP manifested excellent stability in vitro and presented significantly longer sustained release compared to OMT solution in phosphatebuffered saline (pH 7.4). OMT-LIP conspicuously increased OMT accumulation in the degenerative disc, attenuated NP cell apoptosis, reduced the expression of matrix metalloproteinases 3/9 and interleukin-6, and decreased degradation of type II collagen. In in vivo study, X-ray demonstrated that OMT-LIP inhibited IVDD. Conclusion: OMT-LIP may be a useful treatment to alleviate disc inflammation and IVDD.

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Development of a novel liposomal nanoparticle formulation of cisplatin to breast cancer therapy

Cited by 27 publications

References 17 publications

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

<p>Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments</p>

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