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Supplementary Materials…………………………………………………………………………2Supplementary Figures……………………………………………………………………………4 Supplementary Tables……………………………………………………………………………..8 Coding…………………………………………………………………………………………….11
Supplementary Materials Diagnosis of liver cirrhosis:When the patient had a biopsy during this treatment or had a pathological result on the liver parenchyma before this treatment, the diagnosis of liver cirrhosis would be based on the pathological result. Among the 220 patients, 178 were diagnosed by pathological results.When the patient lacked the pathological result, the diagnosis of liver cirrhosis would be based on the combination of the patient's imaging diagnosis and clinical diagnosis. Imaging diagnoses include: abnormal liver morphology, rough liver capsule, tortuous intrahepatic blood vessels and disordered liver parenchyma texture. Clinical diagnosis includes: whether the patient has a history of hepatitis, hepatitis-related serological tests, the patient's drinking history, alcoholic cirrhosis and non-alcoholic cirrhosis-related serological tests. Diagnostic criteria were based on previous studies (References in the main text). Among the 220 patients, 42 were diagnosed by the combination of imaging diagnosis and clinical diagnosis.
Definition of tumor location:Considering the heat sink effect of large vessels and the possible influence of liquid heat dissipation of hepatic blood perfusion on MWA, Couinaud's 8-segment division of liver anatomy was not used in this study. And there was no clear study to confirm that there is a significant difference in the blood perfusion between each segment of the liver. Therefore, in this study, the tumor location was divided into three regions: Near hepatic hilar zone, Intermediate zone and Periphery zone, according to the relative location of the tumor in the liver.The detailed criteria are: first, to determine a line connecting the hepatic hilum to the tumor center to the liver capsule; second, to classify the tumor location according to the position of the tumor center on this line. Taking the hepatic hilum as the origin point and the liver capsule as the distal point. Tumors centered in 0-50% were defined as the Near hepatic hilar zone; in 50-75% were defined as the Intermediate zone; in 75-100% were defined as the Periphery zone (Supplementary figure 4). However, because the tumors located in the Periphery zone are close to the liver capsule, artificial ascites or artificial pleural effusion are often used to protect extrahepatic tissues during MWA, which makes these tumors difficult to delineate their AZs. Therefore, the number of Periphery zone tumors in this study was low.
Ablation needle type, ultrasound type and MRI type:The type of ablation needle used in this study is KY-2450 11mm-type or KY-2450 05mmtype, and the manufacturer is Nanjing Kangyou Medical Instrument Co., Ltd., China Manufacturers of ultrasound used in this study include: Siemens, GE, Hitachi and Mindray Manufacturers of the MRI used in this study include: Siemens and GE
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