Development of a novel polycaprolactone based composite membrane for periodontal regeneration using spin coating technique

Vân, Trần Thị; Makkar, Preeti; Farwa, Ume; Lee, Byong-Taek

doi:10.1080/09205063.2021.2020414

Cited by 14 publications

(9 citation statements)

References 47 publications

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“…Nonetheless, both solutions yielded sharp drops in contact angle when in scaffold form (Figure 7a), and even the control solution was slightly hydrophilic when spin-coated (Figure 7b). As reported elsewhere [42,43], the contact angle of electrospun PCL is ~100 • , which is similar to the initial values of the dynamic contact angle measurements obtained with the control scaffolds, and the ~90 • contact angle of spincoated PCL films measured by others [44]. Although the contact angle tests with the spin-coated membranes suggest the scaffold morphology was responsible for the sudden drop in hydrophilicity, that alone cannot account for the seemingly greater overall hydrophilicity.…”

Section: Discussionsupporting

confidence: 87%

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

Molina¹,

Chen²,

Martinez³

et al. 2022

Materials

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After decades of research, fully functional skin regeneration is still a challenge. Skin is a multilayered complex organ exhibiting a cascading healing process affected by various mechanisms. Specifically, nutrients, oxygen, and biochemical signals can lead to specific cell behavior, ultimately conducive to the formation of high-quality tissue. This biomolecular exchange can be tuned through scaffold engineering, one of the leading fields in skin substitutes and equivalents. The principal objective of this investigation was the design, fabrication, and evaluation of a new class of three-dimensional fibrous scaffolds consisting of poly(ε-caprolactone) (PCL)/calcium alginate (CA), with the goal to induce keratinocyte differentiation through the action of calcium leaching. Scaffolds fabricated by electrospinning using a PCL/sodium alginate solution were treated by immersion in a calcium chloride solution to replace alginate-linked sodium ions by calcium ions. This treatment not only provided ion replacement, but also induced fiber crosslinking. The scaffold morphology was examined by scanning electron microscopy and systematically assessed by measurements of the pore size and the diameter, alignment, and crosslinking of the fibers. The hydrophilicity of the scaffolds was quantified by contact angle measurements and was correlated to the augmentation of cell attachment in the presence of CA. The in vitro performance of the scaffolds was investigated by seeding and staining fibroblasts and keratinocytes and using differentiation markers to detect the evolution of basal, spinous, and granular keratinocytes. The results of this study illuminate the potential of the PCL/CA scaffolds for tissue engineering and suggest that calcium leaching out from the scaffolds might have contributed to the development of a desirable biological environment for the attachment, proliferation, and differentiation of the main skin cells (i.e., fibroblasts and keratinocytes).

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Section: Discussionsupporting

confidence: 87%

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

Molina¹,

Chen²,

Martinez³

et al. 2022

Materials

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“…Synthetic resorbable membranes are designed to be biocompatible and to degrade over time, allowing the body to absorb them and promoting the regeneration of new bone tissue. Some examples of synthetic resorbable membranes for GBR include polylactic acid (PLA), − polyglycolide (PGA), , poly(lactic- co -glycolic) acid (PLGA), , polydioxanone (PDO), , polycaprolactone (PCL), − and polyethylene glycol (PEG) membranes. , However, synthetic bioresorbable membranes also suffer from lack of control over the resorption rate dictated by factors like local pH and lack of inertness because of unfavorable reactions during degradation (Figure ). …”

Section: Synthetic Resorbable Membranesmentioning

confidence: 99%

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

et al. 2023

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Lack of horizontal and vertical bone at the site of an implant can lead to significant clinical problems that need to be addressed before implant treatment can take place. Guided bone regeneration (GBR) is a commonly used surgical procedure that employs a barrier membrane to encourage the growth of new bone tissue in areas where bone has been lost due to injury or disease. It is a promising approach to achieve desired repair in bone tissue and is widely accepted and used in approximately 40% of patients with bone defects. In this Review, we provide a comprehensive examination of recent advances in resorbable membranes for GBR including natural materials such as chitosan, collagen, silk fibroin, along with synthetic materials such as polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene glycol (PEG), and their copolymers. In addition, the properties of these materials including foreign body reaction, mechanical stability, antibacterial property, and growth factor delivery performance will be compared and discussed. Finally, future directions for resorbable membrane development and potential clinical applications will be highlighted.

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“…In vitro evaluation of 3D printed PCL/PLGA composite scaffolds for potential use with human PDL cells indicated significantly enhanced adhesion, proliferation, and osteogenic activity [75,76]. In a rat fenestration defect model, a multi-phase composite scaffold composed of micro-patterned PCL/ PLGA for PDL and amorphous PCL for bone, with PDGF and BMP-7 for spatial delivery from the scaffold, enhanced bone-periodontal ligament interface regeneration (Figure 3) [37,49,52,[77][78][79].…”

Section: Artificial Polymersmentioning

confidence: 99%

Impact exerted by scaffolds and biomaterials in periodontal bone and tissue regeneration engineering: new challenges and perspectives for disease treatment

Santonocito

Ferlito²,

Polizzi

et al. 2023

Exploration of Medicine

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The periodontium is an appropriate target for regeneration, as it cannot restore its function following disease. Significantly, the periodontium's limited regenerative capacity could be enhanced through the development of novel biomaterials and therapeutic approaches. Notably, the regenerative potential of the periodontium depends not only on its tissue-specific architecture and function but also on its ability to reconstruct distinct tissues and tissue interfaces, implying that the development of tissue engineering techniques can offer new perspectives for the organized reconstruction of soft and hard periodontal tissues. With their biocompatible structure and one-of-a-kind stimulus-responsive property, hydrogels have been utilized as an excellent drug delivery system for the treatment of several oral diseases. Furthermore, bioceramics and three-dimensional (3D) printed scaffolds are also appropriate scaffolding materials for the regeneration of periodontal tissue, bone, and cartilage. This work aims to examine and update material-based, biologically active cues and the deployment of breakthrough bio-fabrication technologies to regenerate the numerous tissues that comprise the periodontium for clinical and scientific applications.

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Development of a novel polycaprolactone based composite membrane for periodontal regeneration using spin coating technique

Cited by 14 publications

References 47 publications

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

Impact exerted by scaffolds and biomaterials in periodontal bone and tissue regeneration engineering: new challenges and perspectives for disease treatment

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