Development of a novel polymer-based carrier for deformable liposomes for the controlled dermal delivery of naringenin

Marwah, Mandeep; Badhan, Raj; Lowry, Deborah

doi:10.1080/08982104.2021.1956529

Cited by 15 publications

(9 citation statements)

References 96 publications

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“…A liposome preparation homogenous in size is critical as this will influence tissue distribution in vivo in addition to affecting drug release kinetics. In this study, a desirable polydispersity (up to 0.3) was determined, indicative of a liposomal formulation homogenous in size [ 62 ]. As previously described, depending on the payload of interest and destination target, liposomal complexes can be designed to have a neutral, positive or negative overall charge [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Sodium Thiosulphate-Loaded Liposomes Control Hydrogen Sulphide Release and Retain Its Biological Properties in Hypoxia-like Environment

et al. 2022

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Hypoxia, or insufficient oxygen availability is a common feature in the development of a myriad of cardiovascular-related conditions including ischemic disease. Hydrogen sulphide (H2S) donors, such as sodium thiosulphate (STS), are known for their cardioprotective properties. However, H2S due to its gaseous nature, is released and cleared rapidly, limiting its potential translation to clinical settings. For the first time, we developed and characterised liposome formulations encapsulating STS and explored their potential for modulating STS uptake, H2S release and the ability to retain pro-angiogenic and biological signals in a hypoxia-like environment mirroring oxygen insufficiency in vitro. Liposomes were prepared by varying lipid ratios and characterised for size, polydispersity and charge. STS liposomal encapsulation was confirmed by HPLC-UV detection and STS uptake and H2S release was assessed in vitro. To mimic hypoxia, cobalt chloride (CoCl2) was administered in conjunction with formulated and non-formulated STS, to explore pro-angiogenic and metabolic signals. Optimised liposomal formulation observed a liposome diameter of 146.42 ± 7.34 nm, a polydispersity of 0.22 ± 0.19, and charge of 3.02 ± 1.44 mV, resulting in 25% STS encapsulation. Maximum STS uptake (76.96 ± 3.08%) from liposome encapsulated STS was determined at 24 h. Co-exposure with CoCl2 and liposome encapsulated STS resulted in increased vascular endothelial growth factor mRNA as well as protein expression, enhanced wound closure and increased capillary-like formation. Finally, liposomal STS reversed metabolic switch induced by hypoxia by enhancing mitochondrial bioenergetics. These novel findings provide evidence of a feasible controlled-delivery system for STS, thus H2S, using liposome-based nanoparticles. Likewise, data suggests that in scenarios of hypoxia, liposomal STS is a good therapeutic candidate to sustain pro-angiogenic signals and retain metabolic functions that might be impaired by limited oxygen and nutrient availability.

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Section: Discussionmentioning

confidence: 99%

Sodium Thiosulphate-Loaded Liposomes Control Hydrogen Sulphide Release and Retain Its Biological Properties in Hypoxia-like Environment

et al. 2022

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“…Studies have shown that the topical ionophoretic administration of the developed gel shows a tumor suppression comparable to the invasively applied liposomes. In addition to curcumin, in another study neringenin (an anti-tumor agent with a pronounced antioxidant effect) was included in deformable liposomes dispersed in hydrophilic gels based on hydroxyethyl cellulose (HEC) and hydroxypropyl methylcellulose (HPMC) [135]. The results show that the incorporation of liposomes in the gel leads to a further delay in the release of the drug, with a difference in release in gels based on HEC and HPMC.…”

Section: Nanovesiclesmentioning

confidence: 99%

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Slavkova

Tzankov

Popova

et al. 2023

Gels

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Skin cancer, with all its variations, is the most common type of cancer worldwide. Chemotherapy by topical application is an attractive strategy because of the ease of application and non-invasiveness. At the same time, the delivery of antineoplastic agents through the skin is difficult because of their challenging physicochemical properties (solubility, ionization, molecular weight, melting point) and the barrier function of the stratum corneum. Various approaches have been applied in order to improve drug penetration, retention, and efficacy. This systematic review aims at identifying the most commonly used techniques for topical drug delivery by means of gel-based topical formulations in skin cancer treatment. The excipients used, the preparation approaches, and the methods characterizing gels are discussed in brief. The safety aspects are also highlighted. The combinatorial formulation of nanocarrier-loaded gels is also reviewed from the perspective of improving drug delivery characteristics. Some limitations and drawbacks in the identified strategies are also outlined and considered within the future scope of topical chemotherapy.

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“…The average particle size and PDI of the vesicle were measured before and after extrusion. Novasome deformability was assessed by comparing the particle size between initial and after extrusion [21].…”

Section: Deformability Studymentioning

confidence: 99%

Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat in Vivo Model

2023

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Objective: This study aims to improve the hair-growing effect of bovine placenta extract (PE) by loading it to a novasome vesicle. Methods: PE-loaded novasome was prepared by thin layer hydration method. A 23 full factorial design was used to obtain the most optimum formula by varying the type of surfactants, the type of free fatty acid (FFA), and the ratio of surfactants and FFA. The resulting PE-loaded novasomes were characterized by entrapment efficiency (%EE), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). Results: PE-loaded novasome composed of Span 60: cholesterol: oleic acid (10:10:3) demonstrated the most optimum characteristics with PS 155.0 nm; PDI 0.139; ZP-63.73 and EE 79.60%. Transmission electron microscopy (TEM) of the most optimum novasome revealed non-aggregating oligo-lamellar nanovesicles. In addition, novasome showed ultra-deformable properties and good stability during 90 d storage at 4 °C. A hair growth study in rats showed that the PE-loaded novasome demonstrated better hair-growing effect compared to PE-loaded liposome and minoxidil 2% solution. Conclusion: Novasome is a potential carrier for bringing such a big molecule as PE. PE-loaded in novasome showed vesicles with good physical characteristics and In vivo assessment demonstrated better hair-growing effect than minoxidil and PE-loaded liposomes.

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Development of a novel polymer-based carrier for deformable liposomes for the controlled dermal delivery of naringenin

Cited by 15 publications

References 96 publications

Sodium Thiosulphate-Loaded Liposomes Control Hydrogen Sulphide Release and Retain Its Biological Properties in Hypoxia-like Environment

Sodium Thiosulphate-Loaded Liposomes Control Hydrogen Sulphide Release and Retain Its Biological Properties in Hypoxia-like Environment

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Placenta Extract-Loaded Novasome Significantly Improved Hair Growth in a Rat in Vivo Model

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